4 Best Predictions, Picks for College Football Saturday: Smartest Bets Include Iowa State vs. Oklahoma, Nebraska vs. Wisconsin

The college football Week 12 slate has everything we want as bettors, including early games, late games, big games and low-profile games all offering value.

This doesn't mean that our betting tools are suggesting to make more college football wagers than on a typical  Saturday, but that the smartest sides and totals come from games that will be both public and under-the-radar matchups.

With the help of The Action Network's PRO Report value indicators, let's detail Saturday's four smartest college football bets.

College Football Picks & Predictions

*Odds and betting data as of Friday afternoon

Iowa State vs. Oklahoma Betting Pick

12 p.m. ET | FOX

Iowa State vs. Oklahoma is about as clear-cut as it gets for one-sided, sharp betting action.

This spread opened at Cyclones +5.5 at PointsBet and behind multiple waves of sharp betting has been driven down to a consensus spread of +3.5.

In addition, Iowa State has attracted just 40% of the tickets, but 68% of the money wagered on this spread, showing that big bettors taking the points has forced oddsmakers to adjust this line.

And while the current consensus spread is +3.5, BetMGM is still hanging +4 as of the time of writing, so be sure to snag that number if you plan on tailing the wiseguys in this matchup.

PRO Report Pick: Iowa State +4

Nebraska vs. Wisconsin Betting Pick

3:30 p.m. ET | ABC

Not only are the pros getting down on Nebraska vs. Wisconsin, but two separate historically-profitable betting systems are also aligned with the sharp side of this game.

The latest Nebraska vs. Wisconsin spread sits between Badgers -8.5 and -9, but as I just mentioned, smart money has already shaped this number.