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The Indiana Hoosiers take on the Michigan Wolverines in Ann Arbor, Mich. Kickoff is set for 12:00 p.m. EDT on FOX.
Indiana is favored by -7 points on the spread with a moneyline of -275. The total is set at 41.5 points.
Here’s my Indiana vs. Michigan prediction and college football pick for Saturday, October 24, 2026.
Indiana vs Michigan Prediction
- Indiana vs. Michigan Pick: First Half Under 20.5 or Better
My Michigan vs. Indiana best bet is on the first half under. Find the best line available on our live NCAAF odds page.
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Indiana vs Michigan Odds
| Indiana Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-7 -112 | 41.5 -110o / -110u | -275 |
| Michigan Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+7 -108 | 41.5 -110o / -110u | +225 |
- Indiana vs Michigan point spread: Indiana -7 (-112), Michigan +7 (-108)
- Indiana vs Michigan over/under: 41.5 (-110o / -110u)
- Indiana vs Michigan moneyline: Indiana -275, Michigan +225
Indiana vs Michigan College Football Preview
Indiana Hoosiers Betting Preview: Winning Streak Comes To End
Indiana's 22-game winning streak came to an end as the Hoosiers lost to Ohio State after missed field goals and a few inches out of bounds on a game-winning catch. The home field was electric for the Hoosiers, but now they must regroup and take on a physical Michigan team.
The Hoosiers' offense outgained Ohio State by nearly a full yard per play, creating a methodical and two explosive drives in 12 offensive possessions.
However, Indiana was stuffed well above the national average in 12 of 28 rushing attempts. Quarterback Josh Hoover fought hard through injury, recording 5 big-time throws and 2 turnover-worthy plays.
Coordinator Bryant Haines 4-2-5 defense limited the Ohio State rushing attack, allowing just 3.7 yards per play on 33 attempts. The Buckeyes fell 10 percentage points short of the national average in success rate on standard downs, setting up 15 third-down attempts with an average distance of 7.1 yards.
The Hoosiers defense stood up in the red zone, allowing just a single touchdown on three attempts. Edge Tobi Osunsanmi continues to be a national leader in tackles for loss, ranking second nationally with 11.5 on the season.
Michigan Wolverines Betting Preview: Carr Leads Reignited Offense
Although Michigan beat Penn State by a field goal in State College, the Wolverines posted an 82% post-game win expectancy.
A quarterback change from Bryce Underwood to Tommy Carr was the spark a struggling offense needed after a scoreless first half. Carr led the Wolverines to 21 second-half points on just 5-of-7 passing. The most important statistic was the lack of turnover-worthy plays for the freshman, as Underwood stunted Michigan with 6 interceptions and 6 fumbles this season.
Coordinator Jay Hill saw the Michigan defense energized in the second half against the Nittany Lions, producing three takeaways.
The Wolverines' strength has been on the defensive side all season, ranking as a top-10 team nationally in success rate, EPA allowed, and opponent finishing drives.
A top-20 pass rush is led by a combined 29 pressures from John Henry Daley and Dom Nichols, while middle linebacker Troy Bowles leads the team in tackles with 35.
Indiana vs Michigan Pick, Betting Analysis
Whittingham will start freshman Tommy Carr at quarterback this week.
There's no denying the team's turnaround once Carr entered the game at Penn State. The bulk of the production from the defense, running back Jordan Marshall and the remainder of the team came in the second half.
Carr's presence could keep the momentum going, but it could be an enormous task for a freshman to make his first start against one of the best defenses in the nation.
The Wolverines use power and inside zone for an offense that elects to rush on 60% of snaps. Indiana's defense dominates both run concepts, particularly inside zone at a Success Rate of 68%.
Because the Hoosiers rank third in Rushing Success Rate allowed, Michigan could be forced to move the chains through the air.
Indiana struggled to run the ball against an Ohio State team considered vulnerable to the run. The Hoosiers were stuffed on 43% of attempts and averaged just three yards per play on 28 attempts.
Indiana uses a heavy amount of inside zone, a run concept the Michigan defense dominates. The Wolverines own a 55% Success Rate while producing a negative EPA for opponents that use inside zone.
The success of the Hoosiers' offense could come down to quarterback Josh Hoover against the man, Cover 1 and Cover 3 tendencies used by Michigan. Indiana has been mid-FBS in Success Rate against man and Cover 1, with more success against Cover 3.
Action Network's Betting Power Ratings list Indiana as a 10-point favorite on the road, with the touchdown spread reflecting the Ohio State hangover.
The better bet comes in the first-half under, where Indiana will look to regroup, and Michigan will look for offensive success with Carr under center.
Both defenses are well-suited to stop the bread and butter of the opposing offense, so downfield passing in the second half should determine the winner between Indiana and Michigan.
Pick: First Half Under 20.5 or Better
