Broncos vs. Chargers Odds & Betting Predictions - September 21, 2025

Projection: +165. For more, check out the Fantasy Life player projections.

All NFL Sides + Totals bet on exchanges at significantly better odds

Herbert is off to an excellent this start this season, largely due to an adjustment in offensive mindset for the Chargers. They lead the league in pass rate over expectation through 2 games and are 5th in neutral pass rate. The ground-and-pound nature of this team under Jim Harbaugh and Greg Roman has given way to an aerial attack. The increase in passing plays has boosted Herbert's production on the ground. He's posted 16 carries for 63 yards. After recording 7+ carries in just 2 games last season, he's done it in both games to begin this season. Herbert averaged 1.8 scrambles per game last season. He's up to 3.5 per game so far this season. Herbert has 30+ rushing yards in each game. Denver has played man coverage at the 2nd-highest rate this season. They were 5th last season. Man coverage typically leads to more scramble opportunities, as the defensive backs are focused on their assignments and not looking at the quarterback.

0-2 ATS dogs in Week 3 63-39 (62%) ATS since ‘05, including 21-5 (81%) in Division.

Week 3 fade of a team we’ve probably slightly overrated off 2 wins. The Chargers beat a Chiefs team that can’t move the ball and the Raiders. Off a short week against a division rival, this should be closer to -1/-1.5.

Betting him every game at this price.

@KendraMiddleton_ https://myaction.app/n9oxUJkKLWb

THE BLITZ is forecasting 6.42 rush attempts for Najee Harris compared to 8.75 rush attempts implied by sportsbooks, so I believe there is some value here. If you take the under, you’d be projected to win 69% of the time, resulting in a 45% ROI. Based on a $100 wager, the expected value here would be $45.33. Love THE BLITZ? Get all of Carty’s sports betting projections at https://evanalytics.com/products/nfl-premium-subscription?ref=inf8qq%22%3EEV Analytics!