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Eagles vs. Bills Odds & Betting Predictions - December 28, 2025

Eagles at Bills

9:25 pm • FOX

Philadelphia Eagles

11-5
13
13 - 12

Buffalo Bills

11-5
12

Eagles at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Eagles
11-5
+1.5
+3+100
o45-110
+145
Bills
11-5
u46.5
-3-110
u45-110
-175
location pinSunday 9:25 p.m.
December 28, 2025
Highmark StadiumOrchard Park
Eagles vs. Bills Expert Picks
Jeremiah Rose
Jeremiah Rose
Last 30d: 33-29-1 (-0.7u)
J.Allen Anytime TD Scorer Yes (Live)+220
0.44u
Boyd / FanDuel
Stuck 🚨
Stuck 🚨
Last 30d: 58-48-3 (+3.7u)
BUF +5.5 (Live)-110
0.14u
Live alert
The Propfessor
The Propfessor
Last 30d: 50-46-2 (+3.0u)
S.Barkley o17.5 Longest Rush-108
0.75u
Jeremiah Rose
Jeremiah Rose
Last 30d: 33-29-1 (-0.7u)
Under 46-120
0.33u
Boomer’s Book
YBB SportsData
YBB SportsData
Last 30d: 85-40-0 (+39.3u)
Under 45-110
1u
Scott Rickenbach
Scott Rickenbach
Last 30d: 80-64-0 (+6.9u)
PHI +3-105
0.95u
Markus Markets
Markus Markets
Last 30d: 36-38-0 (-4.2u)
J.Allen 30+ Rushing Yards Yes-125
1u
Vegas Refund
Vegas Refund
Last 30d: 40-35-0 (+1.5u)
PHI +3-108
1u
Picks Office
Picks Office
Last 30d: 171-138-2 (+18.0u)
PHI +1.5-105
0.95u
Join Discord: https://discord.gg/NcyhmJVXPe
Matt DiLeo
Matt DiLeo
Last 30d: 48-33-0 (+7.3u)
J.Hurts u189.5 Pass Yds-112
0.89u
YBK Picks.com
Last 30d: 39-38-0 (-6.0u)
BUF -3-105
2u
Allan Lem
Allan Lem
Last 30d: 167-132-2 (+4.6u)
K.Shakir u4.5 Recs-134
0.67u
Odds aren’t great but projecting this closer to 3.5
Mjaybrod
Mjaybrod
Last 30d: 77-62-0 (+14.1u)
PHI +2.5-102
1.47u
Should have known this was coming
FTN Fantasy
FTN Fantasy
Last 30d: 72-74-0 (-12.3u)
PHI +1.5-110
0.91u
Boomer Betz
Boomer Betz
Last 30d: 101-112-1 (-19.0u)
D.Smith o45.5 Rec Yds-110
$110.00
Kendra Middleton
Kendra Middleton
Last 30d: 16-11-0 (+5.6u)
BUF -1.5-105
1u
Gilles Gallant
Gilles Gallant
Last 30d: 26-74-1 (+1.3u)
J.Hurts Anytime TD Scorer Yes+145
0.7u
J.Hurts 2+ TDs Yes+1100
0.3u
Sandy Plashkes
Sandy Plashkes
Last 30d: 103-125-0 (-42.8u)
D.Smith o48.5 Rec Yds-112
1.12u
Gilles Gallant
Gilles Gallant
Last 30d: 26-74-1 (+1.3u)
J.Allen o0.5 Int+130
0.5u
NFL INT PICKS - W17
DeadPresPicks
DeadPresPicks
Last 30d: 8-6-0 (+2.6u)
BUF -115
0.65u
Cam Is Money
Cam Is Money
Last 30d: 100-95-3 (+0.3u)
J.Cook o11.5 Rec Yds-115
1u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 43-108-5 (+9.3u)
J.Hurts Anytime TD Scorer Yes+145
0.5u
@GDAWG5000 https://myaction.app/oIyNoZLxmZb
T.Johnson Anytime TD Scorer Yes+550
0.5u
@GDAWG5000 https://myaction.app/oIyNoZLxmZb
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 66-114-4 (-5.3u)
BUF -1.5-110
1u
@sundaysixpack @Stuckey2 https://myaction.app/9Vu6o9PHlZb
Sunday Six Pack
Sunday Six Pack
Last 30d: 15-14-1 (-0.2u)
BUF -1.5-110
1.1u
@Stuckey2 3 https://myaction.app/hCTBZDpHlZb
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 22-22-1 (+0.7u)
Under 43.5-105
0.1u
🚀Become a Pro Bettor in 7-Days! (Link in Bio)

Eagles vs. Bills Previews & Analysis

  • NFL Week 17 Picks, Player Props, & Parlays! | Action Playbook LIVE article feature image

    NFL Week 17 Picks, Player Props, & Parlays! | Action Playbook LIVE

    Nick Giffen•
    Dec 29, 2025 UTC
  • Eagles vs. Bills: Prime Spot to Back Josh Allen article feature image

    Eagles vs. Bills: Prime Spot to Back Josh Allen

    Stuckey•
    Dec 28, 2025 UTC
  • Action Analytics: 6 Data-Driven NFL Picks & Parlays for Week 17 article feature image

    Action Analytics: 6 Data-Driven NFL Picks & Parlays for Week 17

    Action Predictive Analytics•
    Dec 28, 2025 UTC
  • Koerner & Raybon's Week 17 Spreads & Totals article feature image

    Koerner & Raybon's Week 17 Spreads & Totals

    Chris Raybon•
    Dec 28, 2025 UTC
See more NFL Coverage Right Arrow

Eagles vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Eagles vs. Bills Public Betting Percentages

Away Logo

Eagles

Public

Home Logo

Bills

57%

Bets%

43%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 4-1 in their last 5 games.
  • Bills are 2-3 in their last 5 games against the spread
  • Bills are 4-4 in their road games against the spread
  • The totals have gone OVER in 4 of Bills' last 5 games
  • The totals have gone OVER in 5 of Bills' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		7-93-54-45-92-0
Eagles		10-64-36-38-61-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		8-85-33-57-71-1
Eagles		6-102-54-56-80-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		11-5N/AN/A9-52-0
Eagles		11-5N/AN/A9-51-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Dec 21st@CLEW 23-20-10.5 LO 41.5BUF -582
Dec 14th@NEW 35-31-2.5 WO 49.5BUF -142
Dec 7thCINW 39-34-6 LO 54.5BUF -285
Nov 30th@PITW 26-7-3 WU 44.5BUF -173
Nov 21st@HOUL 19-23-4.5 LU 44HOU -240

Eagles vs. Bills Injury Updates

Eagles Injuries

    Bills Injuries

    • Curtis Samuel
      WR

      Samuel is out with elbow

      Out

    • Tyler Bass
      K

      Bass is out with hip

      Out

    • Dalton Kincaid
      TE

      Kincaid is out with knee

      Out

    See more NFL Injuries Right Arrow
    Team Stats

    Total

    190
    Total Yards
    331
    54
    Total Plays
    73
    3.5
    Yards Per Play
    4.5

    Passing

    110
    YDS
    262
    13/27
    Comps/Atts
    23/35
    3.857
    YPA
    5.275
    1/0
    TDs/INTs
    0/0
    1/2
    Sacks/Yards
    5/51

    Rushing

    82
    Rush Yards
    120
    26
    Attempts
    33
    3.154
    YPC
    3.636
    0
    TDs
    2

    Turnovers

    0
    Fumbles Lost
    1
    0
    Interceptions
    0

    Efficiency

    1/2 50%
    Redzone
    2/3 66.67%
    3/13 0%
    3rd Down
    6/15 0%
    0/0 0%
    4th Down
    2/3 0%

    First Downs

    11
    Total
    20
    6
    Pass
    11
    4
    Rush
    7
    1
    Penalty
    2

    Misc

    3/36
    Penalties/Yards
    4/40
    24:45
    Possession
    35:15

    Eagles vs. Bills Odds Comparison

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    Eagles at Bills Team Totals

    MatchupOverUnder
    Eagles
    11-5
    o20.5-115
    u20.5-110
    Bills
    11-5
    o24.5-105
    u24.5-120