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Bills vs. Texans Odds & Betting Predictions - November 21, 2025

Bills at Texans

1:15 am • Amazon Prime Video

Buffalo Bills

6-2
@

Houston Texans

3-5

Bills at Texans Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Bills
6-2
N/A
N/A
N/A
Texans
3-5
N/A
N/A
N/A
location pinFriday 1:15 a.m.
November 21, 2025
NRG StadiumHouston

Bills vs. Texans Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Bills vs. Texans Public Betting Percentages

Away Logo

Bills

Public

Home Logo

Texans

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Texans are 2-3 in their last 5 games.
  • Texans are 2-3 in their last 5 games against the spread
  • Texans are 1-3 in their road games against the spread
  • The totals have gone OVER in 1 of Texans' last 5 games
  • The totals have gone OVER in 0 of Texans' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Texans		3-52-21-33-20-3
Bills		4-42-32-12-42-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Texans		2-60-42-21-41-2
Bills		4-43-21-23-31-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Texans		3-5N/AN/A3-20-3
Bills		6-2N/AN/A4-22-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 2ndDENL 15-18-1.5 LU 40.5DEN -122
Oct 26thSFW 26-15-3 WU 41.5HOU -160
Oct 21st@SEAL 19-27+3 LO 41.5SEA +140
Oct 5th@BALW 44-10-2.5 WO 41.5HOU -142
Sep 28thTENW 26-0-7.5 WU 39.5HOU -420

Texans vs. Bills Injury Updates

Texans Injuries

  • Joe Mixon
    RB

    Mixon is out with knee

    Out

  • Tank Dell
    WR

    Dell is out with knee

    Out

  • Cade Stover
    TE

    Stover is out with foot

    Out

Bills Injuries

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Tyler Bass
    K

    Bass is out with hip

    Out

  • Joshua Palmer
    WR

    Palmer is out with ankle

    Out

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Player Stats
  • passing yards
    C.J. Stroud logo
    C.J. Stroud
    1702
    pyds
  • passing touchdowns
    C.J. Stroud logo
    C.J. Stroud
    11
    ptd
  • rushing yards
    Nick Chubb logo
    Nick Chubb
    355
    ryds
  • rushing touchdowns
    Nick Chubb logo
    Nick Chubb
    2
    rtd
Depth Charts
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Starter2ND3RD4TH
QBC.J. StroudDavis MillsGraham Mertz
RBJoe MixonNick ChubbDameon PierceDare OgunbowaleWoody Marks
WRChristian KirkJaylin NoelBraxton Berrios
TEDalton SchultzCade StoverHarrison BryantLuke Lachey
LTAireontae Ersery
LGLaken Tomlinson
CJake AndrewsJarrett PattersonEli Cox
RGEd IngramJuice Scruggs
RTTytus HowardBlake FisherTrent Brown
LDEWill AndersonDarrell TaylorDerek Barnett
RDEDanielle HunterDenico AutryDylan HortonSolomon Byrd
WLBHenry To'oTo'oChristian HarrisJake HansenJackson Woodard
MLBAzeez Al-ShaairE.J. SpeedJamal Hill
LCBDerek StingleyJaylin SmithTremon Smith
SSM.J. StewartJaylen ReedJalen Mills
FSCalen BullockJimmie Ward
RCBKamari LassiterD'Angelo RossDamon Arnette
PTommy Townsend
HTommy Townsend
PRBraxton BerriosJaylin NoelChristian Kirk
KRDameon PierceBraxton BerriosWoody MarksJaylin Noel
LSAustin Brinkman
FBJakob JohnsonBritish Brooks
LWRNico CollinsXavier HutchinsonQuintez Cephus
NBJalen PitreMyles BryantAlijah Huzzie
DTTim SettleFolorunso FatukasiKurt HinishJunior Tafuna
NTSheldon RankinsMario EdwardsTommy TogiaiHaggai Ndubuisi
RWRJayden HigginsTank DellJustin Watson
KKa'imi Fairbairn
Team Stats

Passing

1792
YDS
1698
160/229
Comps/Atts
180/276
8.24
YPA
6.746
13/4
TDs/INTs
11/5
17/95
Sacks/Yards
19/164

Rushing

1292
Rush Yards
871
256
Attempts
214
5.047
YPC
4.07
16
TDs
3

Turnovers

Fumbles Lost
4
Interceptions
5

Efficiency

21/31 67.74%
Redzone
8/22 36.36%
42/92 0%
3rd Down
35/108 0%
3/6 0%
4th Down
9/13 0%

First Downs

185
Total
146
96
Pass
86
71
Rush
40
18
Penalty
20

Misc

/
Penalties/Yards
/
Possession

Bills vs. Texans Odds Comparison

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Bills at Texans Team Totals

MatchupOverUnder
Bills
6-2
N/A
N/A
Texans
3-5
N/A
N/A