Bills vs. Texans Odds & Betting Predictions - November 21, 2025

Bills at Texans

1:15 am • Amazon Prime Video
19 - 23

Bills at Texans Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Bills
7-1
-4.5-110
o44-112
-240
Texans
3-5
+4.5-110
u44-107
+197
location pinFriday 1:15 a.m.
November 21, 2025
Reliant StadiumHouston
Bills vs. Texans Expert Picks
YBK Picks.com
Last 30d: 46-31-3 (+30.1u)
HOU +5.5-105
1.9u
Collin Wilson
Collin Wilson
Last 30d: 88-66-1 (+11.8u)
HOU +5.5-110
1u
Stuck 🚨
Stuck 🚨
Last 30d: 51-57-1 (-0.2u)
HOU +7.5 (Live)-115
0.13u
Kenny Ducey
Kenny Ducey
Last 30d: 1-1-0 (-0.2u)
HOU +5.5-110
1u
Sean Koerner🔮
Sean Koerner🔮
Last 30d: 60-66-1 (+4.9u)
K.Lassiter o7.5 Tackles + Ast+383
0.2u
🪜
N.Collins u5.5 Recs+105
0.53u
Full write up/article in the app
K.Lassiter o5.5 Tackles + Ast+106
0.5u
On the surface this looks like a pretty fair number for Lassiter. He’s averaging 5.8 tackles a game, but my projections flagged this as a potential eruption spot, and it’s easy to see why. The Texans have an elite defense and rank 3rd in average time of possession, so it’s not too surprising they’ve allowed the 4th fewest plays per game. However, they face a Bills offense that ranks 2nd in time of possession, and I’m projecting the Texans to face more play volume tonight with about +1.4 more completions than their season average and, more importantly, +5.9 more rush attempts. Lassiter is a CB who is heavily involved in run defense and actually leads all cornerbacks in run tackles, three more than the next closest player. This matchup specifically favors him. He’s also faced one of the toughest schedules for a CB, and I project him for +5.8 more tackles on the season (+0.58 per game) if he had faced a league-average slate. The Bills provide the 2nd most tackle opportunities to CBs, making this by far his best matchup of the season. The only two teams he’s faced with above-average CB tackle opportunity rates were the Rams (he had 9) and the Broncos (he had 10, and yes, if you remember, I was on his over in that game too). This is the perfect spot for him to rack up 6+ tackles. I’m projecting him closer to 6.7 with around a 65% chance he clears 5.5, and we are also getting plus odds. I’m also going to ladder this. Since the market moves too fast for me to grab multiple rungs, I usually need to pick the one offering the most value. I’m going with 8+ at +383, which I project closer to +180. If you want to sprinkle on any other alts, go for it, because every single one is showing value until the market inevitably moves within minutes.
HOU +3.5 (1H)-115
0.5u
Full write up will be in my TNF betting preview. Out first thing tomorrow
Anthony Dabbundo
Anthony Dabbundo
Last 30d: 41-51-0 (-5.7u)
Under 44.5-110
1u
Doug Ziefel
Doug Ziefel
Last 30d: 366-310-10 (+33.9u)
J.Cook Anytime TD Scorer Yes-105
0.5u
C.Kirk o11.5 Rec Yds-110
0.5u
C.Kirk o1.5 Recs-110
0.5u
N.Chubb o9.5 Rush Att+750
0.2u
N.Chubb o7.5 Rush Att+200
0.25u
N.Chubb o5.5 Rush Att-120
0.5u
W.Marks u66.5 Rush Yds-120
0.6u
Matt DiLeo
Matt DiLeo
Last 30d: 61-41-0 (+13.2u)
D.Mills o7.5 Rush Yds (Live)-114
1u
Placed pregame
Ryan Minion
Ryan Minion
Last 30d: 236-272-8 (-26.0u)
T.Shavers Anytime TD Scorer Yes+500
$1.00
J.Cook o79.5 Rush Yds+120
$1.20
J.Cook o89.5 Rush + Rec Yds-135
$1.00
BUF -5.5-110
$1.10
J.Cook Anytime TD Scorer Yes-105
$1.00
Grant Neiffer
Grant Neiffer
Last 30d: 14-57-1 (-4.1u)
K.Coleman 80+ Receiving Yards Yes+1500
0.1u
K.Coleman 40+ Receiving Yards Yes+270
0.1u
T.Shavers 30+ Receiving Yards Yes+146
0.1u
T.Shavers 60+ Receiving Yards Yes+600
0.1u
T.Shavers 50+ Receiving Yards Yes+400
0.1u
T.Shavers 40+ Receiving Yards Yes+240
0.1u
T.Shavers Anytime TD Scorer Yes+500
0.25u
T.Shavers o21.5 Rec Yds-114
0.57u
K.Coleman o21.5 Rec Yds-114
0.57u
K.Coleman 30+ Receiving Yards Yes+154
0.2u
K.Coleman 70+ Receiving Yards Yes+990
0.1u
T.Shavers 80+ Receiving Yards Yes+1200
0.1u
T.Shavers 70+ Receiving Yards Yes+850
0.1u
K.Shakir Anytime TD Scorer Yes+310
0.25u
K.Coleman 60+ Receiving Yards Yes+680
0.1u
K.Coleman 50+ Receiving Yards Yes+475
0.1u
OldSchool0909
Last 30d: 75-51-0 (+18.8u)
HOU +3.5-110
0.91u
Collin Whitchurch
Collin Whitchurch
Last 30d: 137-191-3 (+5.7u)
N.Collins u5.5 Recs+100
0.5u
K.Lassiter o5.5 Tackles + Ast+106
0.5u
HOU +3.5 (1H)-120
0.5u
Picks Office
Picks Office
Last 30d: 0-0-0 (+0.0u)
BUF -6-105
1u
Link in Bio for early access
Sandy Plashkes
Sandy Plashkes
Last 30d: 103-115-5 (-0.5u)
K.Shakir o42.5 Rec Yds-112
1.5u
@RoyalsProps model play
J.Allen o21.5 Rush Yds (Live)-125
1.25u
Brandon Anderson
Brandon Anderson
Last 30d: 34-99-1 (-8.2u)
HOU +5.5+100
0.5u
I don’t often play these Thursday night games, but this line just feels way off. I make it below a field goal even without Stroud. Houston defense really messed with Allen last time, and Texans have five losses by one score this season, three which would have covered this number. I really think the Texans are live to win outright.
The Degenerates
The Degenerates
Last 30d: 90-83-2 (-0.7u)
BUF u24.5-115
1u
Kyle Murray
Kyle Murray
Last 30d: 123-125-4 (+12.1u)
W.Marks o10.5 Rec Yds-115
1.15u
Will Brinson
Will Brinson
Last 30d: 3-1-0 (+2.4u)
J.Allen Anytime TD Scorer Yes-112
1.12u
Great price here. NINE rushing tds from Week 10-Week 16 last year and he’s going to start pouring it on again as the Bills push for the AFC East.
Brandon Kravitz
Brandon Kravitz
Last 30d: 65-74-1 (+0.3u)
Under 43.5-104
1u
Houston under vs winning teams under Ryans: 17-6. Allen 37-22 to the under on the road.
RoyalsProps
RoyalsProps
Last 30d: 52-60-7 (-15.4u)
K.Shakir o42.5 Rec Yds-110
1u
Gilles Gallant
Gilles Gallant
Last 30d: 20-65-0 (-11.3u)
D.Knox Anytime TD Scorer Yes+400
0.5u
J.Higgins Anytime TD Scorer Yes+525
2.63u
D.Mills Anytime TD Scorer Yes+1400
0.25u
Nick Giffen
Nick Giffen
Last 30d: 48-166-0 (+8.4u)
HOU +5.5-110
0.5u
HOU +3.5 (1H)-125
0.2u
#Tailing @The_Oddsmaker
HOU +225
0.56u
Allan Lem
Allan Lem
Last 30d: 54-43-1 (+0.3u)
HOU +3.5 (1H)-122
0.25u
Action Instagram channel best bet - let’s ride 🚀
N.Collins u5.5 Recs+105
0.5u
Tailing @The_Oddsmaker
Topper
Topper
Last 30d: 73-80-1 (-40.9u)
J.Palmer o2.5 Recs+110
1.6u
7.16% ev
J.Higgins u2.5 Recs+110
0.8u
3.31% ev
J.Allen o1.5 Pass TDs+132
1u
5.44% ev
D.Knox o2.5 Recs+110
0.88u
3.47% ev
HOU +140 (1Q)
0.3u
1.92% ev
Mjaybrod
Mjaybrod
Last 30d: 49-71-1 (-23.5u)
W.Marks Anytime TD Scorer Yes+115
1u
I am hard
Over 41.5 (Live)+102
1.02u
W.Marks 2+ TDs Yes+850
0.25u
Huge woody guy
W.Marks o61.5 Rush Yds-110
0.91u
I got a woody
HOU +6.5 (Live)-110
0.91u
Value
Cam Is Money
Cam Is Money
Last 30d: 0-0-0 (+0.0u)
J.Higgins o27.5 Rec Yds-118
0.85u
G.Davis o20.5 Rec Yds-120
0.83u
💰🦡 Jake
💰🦡 Jake
Last 30d: 93-106-0 (+19.5u)
Under 43.5-105
1u
BUF -3.5 (1H)+100
1u
K.Shakir Anytime TD Scorer Yes+310
0.5u
N.Chubb o20.5 Rush Yds-115
1.15u
Scott Rickenbach
Scott Rickenbach
Last 30d: 101-107-0 (-18.4u)
Under 44.5-115
0.87u
John Feltman
John Feltman
Last 30d: 78-62-2 (+4.6u)
K.Lassiter o5.5 Tackles + Ast-104
9u
New Owner
New Owner
Last 30d: 0-0-0 (+0.0u)
G.Davis Anytime TD Scorer Yes+550
0.25u
Jackcock Entry
BUF -5.5-101
1.01u
Px
Roger Goodell
Roger Goodell
Last 30d: 0-0-0 (+0.0u)
HOU +6-105
0.95u
J.Higgins o26.5 Rec Yds-118
0.42u
Bet Labs
Bet Labs
Last 30d: 4-1-0 (+2.9u)
Over 44-110
1.1u
Derek Carty
Derek Carty
Last 30d: 21-22-1 (+5.6u)
K.Shakir o41.5 Rec Yds-112
1u
THE BLITZ is forecasting 72.88 receiving yards for Khalil Shakir. The oddsmakers' implied projection is 51.31 receiving yards, so I believe there is some value here. If you take the over, you’d be projected to win 72% of the time resulting in a 37% ROI with expected value of $41.32 (based on a $100 wager). (This play is good down to at least -169.) Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz

Bills vs. Texans Previews & Analysis

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Bills vs. Texans Props

Prop Projections

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Line Movement Tracker

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Bills vs. Texans Public Betting Percentages

Away Logo

Bills

Public

73%

Bets%

27%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Texans
3-50-42-12-41-1
Bills
6-23-13-15-21-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Texans
5-33-11-23-32-0
Bills
5-32-23-14-31-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Texans
3-5N/AN/A2-41-1
Bills
7-1N/AN/A6-11-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 16th@TENW 16-13-5.5 LU 37.5HOU -255
Nov 9thJACW 36-29+1.5 WO 37.5HOU -111
Nov 2ndDENL 15-18---
Oct 26thSFW 26-15-3 WU 41.5HOU -160
Oct 21st@SEAL 19-27+3 LO 41.5SEA +140

Bills vs. Texans Injury Updates

Bills Injuries

  • Joshua Palmer
    WR

    Palmer is out with hamstring

    Out

Texans Injuries

  • David Montgomery
    RB

    Montgomery is doubtful with groin

    Doubtful

  • British Brooks
    RB

    Brooks is out with hamstring

    Out

  • Jaylin Noel
    WR

    Noel is out with toe

    Out

Team Stats
326
Total Yards
261
66
Total Plays
56
4.9
Yards Per Play
4.7
253
YDS
153
24/34
Comps/Atts
16/30
4.357
YPA
5.1
0/2
TDs/INTs
2/0
8/70
Sacks/Yards
0/0
143
Rush Yards
108
24
Attempts
26
5.958
YPC
4.154
1
TDs
0

Turnovers

1
Fumbles Lost
0
2
Interceptions
0

Efficiency

0/2 0%
Redzone
2/4 50%
5/16 0%
3rd Down
2/12 0%
3/5 0%
4th Down
1/1 0%

First Downs

14
Total
15
9
Pass
7
5
Rush
6
0
Penalty
2
6/54
Penalties/Yards
5/40
32:22
Possession
27:38

Bills vs. Texans Odds Comparison

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Bills at Texans Team Totals

MatchupOverUnder
Bills
7-1
N/A
N/A
Texans
3-5
N/A
N/A