2021 NFL Week 1 Odds & Schedule: Buccaneers Among Big Favorites in Prime Time Matchups

2021 NFL Week 1 Odds & Schedule: Buccaneers Among Big Favorites in Prime Time Matchups article feature image
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Photo by Cliff Welch/Icon Sportswire via Getty Images. Pictured: Tom Brady, Tampa Bay Buccaneers

  • The full Week 1 schedule for the 2021 NFL season was released on Wednesday
  • Tom Brady's Buccaneers open as big favorites over the Cowboys on opening night
  • See below for the full schedule and betting odds

Tom Brady and the Tampa Bay Buccaneers start the defense of their Super Bowl title in the season-opening Thursday Night Football game as favorites over the Dallas Cowboys.

The full NFL schedule will be announced on Wednesday night, but the Week 1 slate was released in the morning with marquee matchups all over.

Tampa Bay hosting Dallas on Thursday night is one primetime matchup, along with the Chicago Bears against the Los Angeles Rams on Sunday Night Football and the Baltimore Ravens traveling to Las Vegas to take on the Raiders on Monday Night Football.

Elsewhere across the league, the Kansas City Chiefs host the Cleveland Browns, who are hoping to build on last season’s success. A key AFC East showdown between New England and Miami takes place and playoff contenders Pittsburgh and Buffalo square off, too.

New Carolina quarterback Sam Darnold gets an early look at his former team when the Panthers host the Jets.

Read below for the full Week 1 schedule and odds, which are available now at DraftKings.

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NFL Week 1 Odds

Thursday, Sept. 9

Cowboys at Buccaneers (-6.5, 52.5), 8:20 p.m. ET (NBC)

Sunday, Sept. 12

Jaguars (-1.5, 45.5) at Texans, 1 p.m. ET (CBS)

Steelers at Bills (-6.5, 51.5), 1 p.m. ET (CBS)

Jets at Panthers (-5, 43.5), 1 p.m. ET (CBS)

Cardinals at Titans (-2.5, 51.1), 1 p.m. ET (CBS)

Chargers at Washington (-1.5, 45), 1 p.m. ET (CBS)

Vikings (-2.5, 48.5) at Bengals, 1 p.m. ET (FOX)

49ers (-7, 46.5) at Lions, 1 p.m. ET (FOX)

Eagles at Falcons (-3.5, 46.5), 1 p.m. ET (FOX)

Seahawks at Colts (-2.5, 52.5), 1 p.m. ET (FOX)

Browns at Chiefs (-5.5, 53), 4:25 p.m. ET (CBS)

Dolphins at Patriots (-2.5, 45.5), 4:25 p.m. ET (CBS)

Broncos (-1.5, 42.5) at Giants, 4:25 p.m. ET (FOX)

Packers at Saints (no line yet), 4:25 p.m. ET (FOX)

Bears at Rams (-7, 45), 8:20 p.m. ET (NBC)

Monday, Sept. 13

Ravens (-5.5, 51.5) at Raiders, 8:15 p.m. ET

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