The New York Giants host the Kansas City Chiefs in the NFL Week 3 edition of Sunday Night Football on Sept 21. Chiefs vs Giants kicks off at 8:20 p.m. ET at MetLife Stadium in East Rutherford, N.J. The game will be broadcast on NBC.
The Chiefs are 6-point favorites on the spread over the Giants (Chiefs -6); the game total is set at 44.5. The Chiefs are -600 moneyline favorites to win and the Giants are +245 underdogs.
Below you can find our three Chiefs vs Giants predictions for Sunday Night Football, which include picks for the spread, over/under and player props.
Chiefs vs Giants Predictions
| Game | Time (ET) | Best Bet |
|---|---|---|
  | 8:20 p.m. | |
| 8:20 p.m. | |
| 8:20 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Chiefs vs Giants Odds
- Chiefs-Giants Moneyline: Chiefs -300, Giants +245
- Chiefs-Giants Spread: Chiefs -6 (-110), Giants +6 (-110)
- Chiefs-Giants Total: 44.5
Chiefs vs Giants Spread Prediction
The Chiefs have not been a profitable team to back as substantial favorites, but this is a good spot for them to win by margin.
Patrick Mahomes has covered at a 56.6% rate on the road over the entirety of his career. He’s only taken the field three times as a road favorite coming off two consecutive losses, but the Chiefs are 2-0-1 against the spread (ATS) in that exact scenario.
The Giants defense surrenders nearly 40 yards per possession, which ranks 30th in the league. Teams have consistently moved the ball against their overmatched defense. The Giants have three excellent defensive linemen yet they struggle to generate pressure on opposing quarterbacks, ranking 22nd in pressure rate (33%) through two games.
The lack of a running game for the Giants is also a major concern.
New York ranks 28th in adjusted line yards per rush attempt, which means its entire offensive performance will rest on the arm of veteran QB Russell Wilson. He had a vintage performance in Dallas last week, but his passer rating when pressured is a putrid 52.7 this season.
Steve Spagnuolo’s Chiefs defense will undoubtedly bring the heat on the numerous third-down situations the Giants are certain to face.
Lay the points with the Chiefs in what will be a complete and complementary bounce-back performance.
Pick: Chiefs -6
Chiefs vs Giants Over/Under Pick
By Billy Ward
While I expect the Chiefs to ride out this rough patch, I’m not so sure the turnaround starts tonight on Sunday Night Football.
They’re still without Xavier Worthy and Rashee Rice, and Travis Kelce might be over the hill. He’s caught just 6-of-10 targets so far this season, including the costly drop in the end zone last week that is a huge part of the Chiefs being winless.
While the Eagles and Chargers have solid defenses, the Giants' elite pass rush makes them at least as good as the Chargers, making a Week 3 breakout for Patrick Mahomes and company unlikely.
On the other side, the Giants will have their big plays, but I doubt their ability to sustain production against anyone except the league’s bottom-tier defenses (like the Cowboys). The Giants' true ability is probably close to the six points they scored against the Commanders than the 37 they put up against Dallas.
BetMGM has a slightly off-market line of 45, with no extra juice on the under. That’s enough for me in what should be a relatively low-scoring Chiefs win.
Pick: Under 45
Chiefs vs Giants Player Props
The Chiefs were already shorthanded at the wide receiver position to start the season due to the suspension of Rashee Rice.
However, Kansas City’s WR situation got much worse quickly in their season opener when Xavier Worthy exited with a shoulder injury — he will remain sidelined for tonight’s matchup against the Giants.
Marquise "Hollywood" Brown had a tough day as the Chiefs’ top option out wide against the Eagles last week, catching all five of his targets for 30 yards in a game in which Kansas City only scored 17 points.
That said, Brown’s five receptions still led the Chiefs and he tied for second on the team in targets, only behind Travis Kelce (6).
The Eagles’ defense is undeniably tough, highlighted by the Birds holding the Chiefs and Cowboys to 20 points or fewer in back-to-back games to open the season. But their secondary is a bit lopsided, with two great, young DBs in Quinyon Mitchell and Cooper DeJean, while the rest of the crew leaves plenty to be desired.
Patrick Mahomes is a quarterback who knows how to take what the defense gives him, and after targeting Brown 16 times following Worthy’s exit in Week 1, and connecting with him for 10 receptions for 99 yards, the Eagles clearly had no intentions of letting him do that again.
Even with the added defensive focus placed on Brown last week, he still managed to haul in five passes, which is one short of his receptions line for tonight.
I think we’ll see him fly under the radar a little bit in film study this week, and at the very least, land somewhere between the 10 and five receptions he tallied in the first two weeks of the season.
Pick: Hollywood Brown Over 5.5 Receptions (+100)
