Week 2 of the 2026 NFL season is stacked with early-afternoon matchups, and the prediction markets around them are already moving.
If you haven't traded on these contracts before, be sure to read our full Polymarket review before you get started. Once you're set up, download the Action Network app for more picks and analysis on every game this week, and keep an eye out for a Polymarket promo code that can boost your contract.
NFL Combos to Trade Now on Polymarket
A prediction market works a lot like a stock exchange: the price of a contract shifts as more people trade one side over the other, and that price reflects where the crowd currently sees an outcome landing. The moneyline, or who wins outright, is only the starting point.
Every game on Sunday's board also carries contracts on the total points, the spread, team-specific scoring, and pre-built combos that bundle two or three of those outcomes into a single contract with a bigger payout if all of them hit.
Cincinnati's Road Price Looks Off
The Bengals are 1-0 after outlasting Tampa Bay in Week 1, yet Cincinnati still sits as the underdog heading into Houston, largely because Joe Burrow spent the week working through back tightness. Burrow pushed through practice anyway, telling reporters that missing the game would be "ridiculous."
With Ja'Marr Chase and Tee Higgins both healthy, Cincinnati's offense has enough juice to keep pace even if Houston controls the game script.
The "Who Dey score" combo, pairing the Bengals' moneyline with the over at 46.5, prices out at 4.81x: a gap between record and respect that's worth a second look.
Green Bay's Line Trouble Sets Up a Low Number
New York opened 1-0 with Geno Smith spreading targets to eight different receivers in a win over Tennessee, while Green Bay's offensive line gave up four sacks and left Jordan Love running for his life on well over half the offense's drop-backs in a loss to Minnesota.
The Jets' front seven ranked third in the league in pass-rush win rate in Week 1, a real edge against a Packers line still sorting out its best five up front.
The "Green Down" combo pairs the Jets' moneyline with the under at 42.5, at 5.3x.
A Cross-Country Combo on Both Coasts
This one ties two Sunday games together through the same thread: a shaky situation at quarterback on the other side for the "Desert Heist" combo.
In Los Angeles, Justin Herbert and the Chargers are still searching for answers after an upset loss to Arizona, while the Raiders arrive off a win in which Kirk Cousins and Ashton Jeanty controlled the clock for most of the second half.
In Seattle, the Seahawks will start Drew Lock in place of Sam Darnold, who's dealing with a hip injury: a real downgrade against a Cardinals team that just knocked off the Chargers on the road.
Pairing the Raiders and the Cardinals into one contract prices at 10.0x, leaning on two offenses catching a favorable spot on the same afternoon.
Three Spreads, One Theme: Backup Quarterbacks
The widest combo of the week strings together three home favorites, each facing an opponent with a thinner situation on offense.
Baltimore hosts a Saints defense that just allowed 14 completions on 17 short-range attempts against Detroit. Chicago, coming off a 59-point outburst behind Caleb Williams, gets a Vikings team likely to start Carson Wentz again with Kyler Murray still in the concussion protocol.
And San Francisco opens as the biggest favorite of the week at -13.5 against a Dolphins offense that gave up five sacks in its opener and is adjusting to a new starter under center.
The "Raven Bear Gold Rush" combo bundles all three at 8.62x, which raises the payout along with the number of things that need to break right.
