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49ers vs. Cardinals Odds, Pick, Prediction: Monday Night Football’s NFL Betting Model Edge (November 21)

49ers vs. Cardinals Odds, Pick, Prediction: Monday Night Football’s NFL Betting Model Edge (November 21) article feature image
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Photo by Ronald Martinez/Getty Images. Pictured: Arizona Cardinals quarterback Colt McCoy

  • NFL Week 11 concludes with the San Francisco 49ers taking on the Arizona Cardinals in Mexico City.
  • NFL odds show the 49ers as big spread favorites over the Cardinals, with Monday night's over/under sitting at 43.
  • Continue reading to see the NFL betting model pick that experts are making for 49ers vs. Cardinals on Monday Night Football.

49ers vs. Cardinals Odds

49ers Odds -9
Cardinals Odds +9
Over/Under 43
Date Monday, Nov. 21
Time 8:15 p.m. ET
Channel ESPN

*Odds as of Monday morning

NFL Week 11 concludes with the San Francisco 49ers taking on the Arizona Cardinals on Monday Night Football in Mexico City.

According to NFL Network’s Ian Rapoport, Kyler Murray’s injured hamstring is expected to sideline him tonight, paving the way for backup quarterback Colt McCoy to start for Arizona on Monday Night Football.

This appears to be reflected in the latest NFL odds for 49ers vs. Cardinals, evidenced by the 8.5-point spread.

With McCoy under center, tonight’s game may not be as competitive as it would have been, at least on paper, if Murray were healthy, but as NFL bettors all we care about is value.

And according to the Action Network’s NFL picks and predictions, experts are dropping big bucks on a betting model edge for 49ers vs. Cardinals on Monday Night Football.

Let’s take a look.

49ers vs. Cardinals Pick