Our football staff is focused on six of Sunday's biggest games for our NFL predictions in Week 10 on November 9.
First, we'll focus on Buccaneers vs Patriots and Ravens vs Vikings in the early window. Later in the afternoon, we have a pick for Cardinals vs Seahawks. We also have picks for Bears vs Giants, Browns vs Jets, and more.
Let's dive into our expert NFL picks and best bets for the Week 10 Sunday slate.
NFL Predictions & Picks — Week 10
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  | 4:05 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Patriots vs Buccaneers Spread Prediction
The Buccaneers are fresh off of their bye, and the Patriots have been the beneficiary of one of the easiest schedules in the NFL.
The Bucs rushing defense is particularly strong, but their pass defense is not.
We know Baker Mayfield can be explosive in the passing game, but can Drake Maye keep up?
I am going to say "No."
I think the Bucs win big off of their bye week.
Pick: Buccaneers -2.5 (-110)
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Ravens vs Vikings Best Bet
By Brit Devine
The Vikings got a decisive victory over the Lions last week and seem to be getting way too much credit for this one.
The Ravens got back on track last week with a healthy offense after their bye week and should be back to being one of the most dangerous offenses in football. Their defense isn't as great as it has been, but I am not sold on J.J. McCarthy at all as a starting-caliber NFL QB yet.
McCarthy has 153 yards or fewer passing in his three NFL starts and is clearly being handled like a game manager by his coaching staff. His 57.6% completion percentage hovers near the levels of Cam Ward and Tyler Shough.
The Vikings won last week's game on the back of Aaron Jones and a blitz-heavy defense.
The one thing you don't want to do against the Ravens is blitz, as Lamar Jackson has been one of the best in the league against the blitz since last season.
That sounds like trouble for the Vikings, who blitz at the highest rate in the league.
Aaron Jones got hurt last week, but he is expected to play today.
With nothing at QB and a weakened run game, there is almost no chance for the Vikings to keep up with the Ravens in this one.
Pick: Ravens -4 (-110)
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Bears vs Giants Over/Under Pick
By Bet Labs
The NFL system titled "High Winds" is built on how weather directly impacts offensive efficiency and scoring potential.
When average wind speeds climb into the double digits, passing games struggle with accuracy, kicking becomes unreliable, and play calling leans more heavily toward conservative runs.
This naturally limits explosive plays and lowers scoring opportunities.
With temperatures sitting in a reasonable range that does not drastically impact player stamina or ball handling, wind becomes the defining variable.
Both regular season and postseason games fit this mold, as weather remains an equalizer regardless of stakes.
Betting the under in these conditions takes advantage of how the market often undervalues the true effect of sustained wind on football outcomes.
Pick: Under 46.5 (-110)
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Browns vs Jets Spread Best Bet
I can't believe I'm saying this, but the Browns look like an outstanding option as short road favorites against the Jets today.
The Jets traded away all of their best defensive players at the deadline, and the defense was already struggling.
Garrett Wilson should return, but this Browns defense is still one of the best in the league, and should have no problem slowing down the Jets.
Pick: Browns -2 (-110)
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Saints vs Panthers Best Bet
By Bet Labs
The system titled "Road 'Dog Low Total After Bad Season" focuses on how struggling NFL teams from the previous year can quietly outperform expectations when catching points on the road in lower scoring games.
Teams with six or fewer wins from the prior season (like the Saints) are often undervalued, but when they are priced as moderate underdogs in contests with totals capped at 50, the environment favors closer outcomes and makes points more valuable.
Playing early or late in the year amplifies this effect, as early games offer a chance for redemption, while late season contests often bring unique motivations and divisional familiarity.
In these situations, public bias against bad teams collides with the natural tendency for low total games to stay tight, creating profitable opportunities for road underdogs to cover.
Pick: Saints +5.5 (-110)
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Cardinals vs Seahawks Best Bet
By Bet Labs
The system titled "Great Condition Divisional Road 'Dogs" works on the belief that divisional underdogs traveling in good weather during the early and middle parts of the season carry hidden value.
In the NFL, division games are often tighter and more unpredictable because of the familiarity and rivalry factor, which narrows the talent gap.
When the visiting team is the 'dog in November, conditions are generally stable with limited wind allowing both teams to execute their normal game plans without weather being a major factor.
In these spots, the public often overvalues the home side, yet divisional familiarity and the motivational boost of playing a rival make the road 'dog more competitive than the line suggests.
In this particular case, the Cardinals have a deceptive record. Their largest margin of defeat this season is four points and their offense looks rejuvenated with Jacoby Brissett playing quarterback over Kyler Murray.
Pick: Cardinals +6.5 (-110)
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