Our staff is focused on six of Sunday's biggest games for our NFL predictions in Week 4 on September 28.
First, we'll focus on the early morning clash in Dublin between the Vikings and Steelers. Later in the afternoon, we have a pair of total predictions for Titans vs Texans and Jaguars vs 49ers. We also have two picks against the spread for Chargers vs Giants and Ravens vs Chiefs, plus more.
Let's dive into our experts' NFL picks and predictions for the Week 4 Sunday slate.
NFL Predictions, Week 4 Picks
| Game | Time (ET) | Pick |
|---|---|---|
  | 9:30 a.m. | |
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 4:25 p.m. | |
  | 4:05 p.m. | |
  | 8:20 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Vikings vs Steelers Moneyline Pick
By Brit Devine
The Vikings are the better team in this matchup by a good margin.
The Steelers have survived this season by winning the turnover battle, which is something they somehow always seem to do under Mike Tomlin, and they could very easily be 0-3 heading into this one overseas.
The Steelers might meet their match in that department, as the Vikings are also notoriously good at winning the turnover battle under DC Brian Flores, who is scheming up defensive pre-snap movement that has never been seen before in the NFL; he continuously stays a step ahead of the NFL offensive tendencies.
The Steelers' offense is operating horribly, with the 3rd-lowest yards per game on offense in the league and the 8th-lowest yards per play.
Vikings' HC Kevin O'Connell has been able to get the most out of the QB position over the years, and even with Carson Wentz, the Vikings should be able to put up points against a Steelers' defense that is full of good players but are now well past their prime.
As a unit, the Steelers are giving up the 5th-most yards per game.
Pick: Vikings Moneyline (-140)
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Titans vs Texans Total Prediction
Texans' games continue to be elite under spots.
Houston's defense is pretty much what we expected as one of the tougher units in the entire NFL, and the horrible offensive line and lack of talent creates one of the weaker offensive units in the league.
Through the first three weeks of the season, the Texans have been the 4th-worst offense in EPA per play, while the Titans have been 7th-worst.
Pick: Under 39.5 (-110)
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Chargers vs Giants Bet Labs System
By Bet Labs
The system titled "Game in EST, Road team Traveling From PST/MST (first five games since 2019)" backs teams traveling from the Pacific or Mountain time zones when they play in the Eastern time zone early in the season, which is the case for the Chargers in this week's matchup against the Giants.
In the opening stretch, rosters are fresh, staffs build in extra preparation and acclimation, and body clocks have not settled into rigid weekly rhythms, so the long trip is less taxing than it becomes later in the season.
The market still prices the old narrative that west coast teams struggle in early kickoffs, which tilts numbers toward the home side.
With modern travel routines, sports science, and simplified early game plans, these visitors tend to execute cleanly, and either keep games inside the number or win outright.
The edge shows up in the first five games across regular season, as freshness and planning outweigh the travel tax and create value on the road team.
Pick: Chargers -6.5 (-110)
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Ravens vs Chiefs ATS Pick
I love the Ravens in this spot.
The Chiefs are simply not the same team we've seen in years past. And while the Ravens are off to a 1-2 start, their two losses were very close losses on the road at Buffalo and Detroit, which is nothing to be ashamed of.
The Chiefs get Xavier Worthy back for this game, but the offense has been rather anemic, and their defense is in for a whole new challenge against an elite Ravens' offense.
Pick: Ravens -2.5 (-115)
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Jaguars vs 49ers Over/Under Bet
The 49ers lost Nick Bosa, which is a big deal, but they've been a stout defense so far this season across the board.
The Jaguars' offense has not taken much of a leap thus far under new head coach Liam Coen, with struggles among the pass catchers and Trevor Lawrence.
The Niners' offense has been a shell of its former self as well, with the injuries mounting on that side of the football.
Brock Purdy is expected to return for this game, but he likely won't be 100% healthy coming off an injury, and he will dealing with a severe lack of talent given the rest of the team's absences.
Pick: Under 46.5 (-110)
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Packers vs Cowboys SNF Best Bet
By Kyle Murray
This Packers' team is coming off of a brutal showing last week, as they scored just 10 points against the Browns and lost 13-10.
However, things are looking bleak for this Cowboys' team.
Dallas was just run out of Solider Field last week, as they have one of the worst defenses in football, and now they will have to play this game without CeeDee Lamb and offensive lineman Tyler Booker.
Let's lay the points with Green Bay on Sunday night.
Pick: Packers -6.5 (-115)
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