French Open Men’s Predictions for Musetti vs Rune, Tiafoe vs Altmaier

The fourth round of the French Open begins in Paris on Sunday, and there are plenty of matches to like from a betting perspective. Let's look at a pair of Roland Garros matches below.

Here are my previews and French Open predictions for Frances Tiafoe vs Daniel Altmaier and Lorenzo Musetti vs Holger Rune on Sunday, June 1.

Quickslip

+730 French Open Parlay

French Open Predictions, Picks, Odds — Men's Fourth Round

Musetti vs Rune Odds

Even though he did not win a title this year, Lorenzo Musetti had a great clay season. He lost the Monte-Carlo final to Carlos Alcaraz, then the Madrid semifinal to Jack Draper and then another semifinal in Rome, again to Alcaraz.

Musetti is currently World No. 7 but is fourth in the clay EloRatings rankings with a 64.9 winning percentage on this surface. His 2025 record on clay is 14-3, and we just went through the list of who he lost to.

Having reached the fourth round in 2021, this will be his career performance at the French Open if he advances. So far, the Italian has been really solid in Paris, losing only the first set of his third-round match against Mariano Navone.

With a well-rounded game and a good serve, Musetti has earned the title of favorite in this match, even though his opponent, Holger Rune, prevails in the head-to-head.

Rune won both times they met, one on the hard court and the other on the grass. The Dane did not last long in three of the four clay tournaments he played in preparation for Roland Garros, but he won the one he did — the ATP 500 in Barcelona, where he defeated Alcaraz in the final.

Rune has struggled a bit more this week, losing a set to Roberto Bautista Agut and needing to win the last two against Quentin Halys to advance to this round.

They are both great clay players, but Musetti likely takes this one, given his performance in Paris.

Pick: Musetti -4.5 (-110 via DraftKings)

Tiafoe vs Altmaier Odds

Despite a lackluster clay season, Frances Tiafoe has proven his skills on this surface in Paris this week, already achieving his best career performance at the French Open.