Jannik Sinner and Alexei Popyrin square off in the second round of the US Open today. The match is tentatively scheduled to start at 12:40 p.m. ET on Arthur Ashe Stadium and will be broadcast on ESPN.
Sinner started his US Open title defense with authority and will face a better challenger in Popyrin, ranked 36th on the ATP Tour.
Find my Sinner vs Popyrin prediction and US Open pick for Thursday, August 28 below.
Jannik Sinner vs Alexei Popyrin Prediction, Odds
| Sinner Odds | -5000 |
| Popyrin Odds | +1100 |
| Spread | Sinner -7.5 (-160), Popyrin +7.5 (+110) |
| Over/Under | 30.5 (-115o / -125u) |
| Sinner-Popyrin H2H | 0-1 |
| Time | How to Watch | Thursday, 12:40 p.m. ET | ESPN |
| Odds via BetMGM | |
Jannik Sinner vs Alexei Popyrin Preview, Prediction
Jannik Sinner Betting Preview
Sinner isn't only the defending US Open champion but also the current holder of the Australian Open and Wimbledon titles. If it weren't for Carlos Alcaraz's remarkable comeback from 2-0 down in the Roland Garros final, Sinner would be holding all four Grand Slams.
Sinner also crushed the competition in his only hard-court season tournament, the Cincinnati Masters 1000, until he met Alcaraz again in the decisive match. This time, illness beat him, not the Spaniard. The Italian didn't feel well and ended up retiring after losing five straight games in the first set.
His performance on Tuesday dispelled any doubts regarding his condition. Sinner dismissed Vit Kopriva in one hour and 38 minutes, with a 6-1, 6-1, 6-2 score line, recording seven aces and winning 83% of his first-serve points.
The world No. 1 is here to collect his second US Open title and fifth Grand Slam, and will be considered the favorite in every match in this tournament, even if the opponent's last name is Alcaraz.
Alexei Popyrin Betting Preview
Not many players can say they have a winning record against Sinner, so it's curious that Popyrin, of all people, is one of them.
The Australian won the only matchup of their head-to-head back in 2021, on a clay court at the Madrid Masters 1000. He didn't even lose a set; the score was 7-6(5), 6-2.
