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Athletics vs Guardians Prediction, Pick, MLB Odds for Saturday, September 19

Athletics vs Guardians Prediction, Pick, MLB Odds for Saturday, September 19 article feature image
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Photo Credit: Bruce Kluckhohn-Imagn Images
Pictured: Jo Adell advances to third base

The Cleveland Guardians host the Athletics on September 19, 2026. First pitch from Progressive Field is scheduled for 6:10 p.m. EDT. The game will be broadcast on CLEG.

The Guardians are favored by -185 on the moneyline and by -1.5 on the run line. The Athletics are +152 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.

Find my MLB picks and Athletics vs Guardians prediction below, as well as probable pitchers, weather report, and more.


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Athletics vs Guardians Prediction

  • Athletics vs Guardians Pick: Jo Adell Over 0.5 Home Runs (+450)

My Athletics vs Guardians best bet is on Adell to record 1+ home runs. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.


Athletics vs Guardians Odds

Athletics Logo
September 19, 2026
6:10 p.m. EDT
CLEG
Guardians Logo
Athletics Odds
SpreadTotalMoneyline
+1.5
+116
7.5
-115o / -105u
+152
Guardians Odds
SpreadTotalMoneyline
-1.5
-140
7.5
-115o / -105u
-185
Odds via bet365. Get up-to-the-minute MLB odds here.
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  • Athletics vs Guardians moneyline: Athletics +152, Guardians -185
  • Athletics vs Guardians over/under: 7.5 (-115o / -105u)
  • Athletics vs Guardians spread: Guardians -1.5 (+116 ), Athletics +1.5 (-140)

Athletics vs Guardians Probable Pitchers

Jacob LopezStatTanner Bibee
6-4W-L6-15
0.9fWAR (FanGraphs)1.3
5.02 / 3.52ERA / xERA4.16 / 4.29
5.07 / 5.17FIP / xFIP4.59 / 4.50
10K-BB%11.8
31.6GB%36.6
.290BABIP.255
98Stuff+102
103Location+100

Athletics vs Guardians MLB Betting Preview

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Athletics vs Guardians Pick, Betting Analysis

Jacob Lopez has been hammered by righty power this season, allowing a massive 1.97 HR/9. I have the true odds on Jo Adell around +375.

Pick: Jo Adell Over 0.5 Home Runs (+450)


Athletics vs Guardians Weather


Get the latest coverage on MLB Weather.


Author Profile
About the Author
Grant NeifferVerified Action Expert

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