The Cleveland Guardians host the Athletics on September 19, 2026. First pitch from Progressive Field is scheduled for 6:10 p.m. EDT. The game will be broadcast on CLEG.
The Guardians are favored by -185 on the moneyline and by -1.5 on the run line. The Athletics are +152 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Athletics vs Guardians prediction below, as well as probable pitchers, weather report, and more.
- Athletics vs Guardians Pick: Jo Adell Over 0.5 Home Runs (+450)
My Athletics vs Guardians best bet is on Adell to record 1+ home runs. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.
Athletics vs Guardians Odds
| Athletics Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 +116 | 7.5 -115o / -105u | +152 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -140 | 7.5 -115o / -105u | -185 |
- Athletics vs Guardians moneyline: Athletics +152, Guardians -185
- Athletics vs Guardians over/under: 7.5 (-115o / -105u)
- Athletics vs Guardians spread: Guardians -1.5 (+116 ), Athletics +1.5 (-140)
Athletics vs Guardians Probable Pitchers
| Jacob Lopez | Stat | Tanner Bibee |
|---|---|---|
| 6-4 | W-L | 6-15 |
| 0.9 | fWAR (FanGraphs) | 1.3 |
| 5.02 / 3.52 | ERA / xERA | 4.16 / 4.29 |
| 5.07 / 5.17 | FIP / xFIP | 4.59 / 4.50 |
| 10 | K-BB% | 11.8 |
| 31.6 | GB% | 36.6 |
| .290 | BABIP | .255 |
| 98 | Stuff+ | 102 |
| 103 | Location+ | 100 |
Athletics vs Guardians MLB Betting Preview

Athletics vs Guardians Pick, Betting Analysis
Jacob Lopez has been hammered by righty power this season, allowing a massive 1.97 HR/9. I have the true odds on Jo Adell around +375.
Pick: Jo Adell Over 0.5 Home Runs (+450)




































