Athletics vs Twins Prediction, Pick, Odds for Thursday, August 21

Athletics vs Twins Prediction, Pick, Odds for Thursday, August 21 article feature image
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Pictured: Jack Perkins. (Credit: Ed Szczepanski-Imagn Images)

The Minnesota Twins host the Athletics on August 21, 2025. First pitch from Target Field is scheduled for 1:10 p.m. EDT; the game will be broadcast on NBCS-CA.

Find my MLB betting preview and Athletics vs Twins prediction below, as well as probable pitchers, betting trends, injury reports and more.

Quickslip

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My Athletics vs Twins Prediction

  • Athletics vs Twins pick: Athletics Moneyline

My Athletics vs Twins best bet is on the Athletics to win outright. Make sure to find the best odds by checking our live MLB odds page.


Athletics vs Twins Odds

Athletics Logo
Thursday, Aug 21
1:10 p.m. ET
NBCS-CA
Twins Logo
Athletics Odds
SpreadTotalMoneyline
-1.5
+145
undefined
o / u
-115
Twins Odds
SpreadTotalMoneyline
+1.5
-175
undefined
o / u
-105
Odds via BetMGM. Get up-to-the-minute MLB odds here.
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Athletics vs Twins Projected Starting Pitchers

RHP Jack Perkins (ATH)StatRHP Jose Urena (MIN)
2-2W-L0-0
0.4fWAR (FanGraphs)-0.1
4.28/3.16ERA /xERA4.06/7.23
3.92/4.08FIP / xFIP5.60/5.19
1.13WHIP1.42
15.1%K-BB%4.5%
42.7%GB%32.0%
107Stuff+84
91Location+105

Tony Sartori’s Athletics vs Twins Preview

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Athletics Betting Preview: Rookie Perkins Leads the Athletics' Charge

A fifth round draft pick in 2022, the Athletics' Jack Perkins has looked sharp in his rookie campaign. Through 11 appearances on the mound, Perkins possesses a 4.28 ERA and 1.13 WHIP.

Not only has he handled both bullpen and rotation duties well, but his underlying metrics suggest even more success moving forward. Entering this matchup, Perkins boasts a 3.15 xERA and .217 xBA.

If he officially qualified, the right-hander would rank in the top quarter of the league in average exit velocity, whiff rate and hard-hit rate.

Perkins should also receive plenty of run support. This season, the Athletics rank in the top five in hits per game, BA, SLG and OPS.


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Minnesota Twins Betting Preview: Bats Need a Spark

The clear hitting advantage in this matchup goes to the Athletics. Minnesota fails to crack the top half of the league in each of those four aforementioned categories.

These hitting woes are likely to continue against Perkins. Not only does the right-hander profile well, but not a single member of the Twins has faced him prior to Thursday.

It will likely take a few rotations through the batting order to attempt to figure him out, and by then, it may be too late. Furthermore, Minnesota's bullpen can't be trusted.

Entering this matchup, the Twins' relief corps ranks 23rd in ERA.


Athletics vs Twins Prediction, Betting Analysis

There are many reasons to like the Athletics at -102 in this spot. Perkins has thrown well since entering the starting rotation, and his analytics suggest to expect even stronger outings moving forward.

Meanwhile, the clear hitting advantage belongs to the Athletics. While Minnesota boasts home-field advantage, these two teams' road/away winning percentages are nearly identical.

Pick: Athletics Moneyline (-120, Fanatics)


Moneyline

As mentioned, I'm betting the Athletics moneyline.


Run Line (Spread)

I also like the Athletics to cover, but I find more value in just taking the outright moneyline price.


Over/Under

I lean toward the over, but don't want to fade Perkins.


Athletics vs Twins Betting Trends


Athletics vs Twins Weather


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About the Author
Tony Sartori is a sports betting writer for Action Network. He has published over 1,000 sports betting articles for various media outlets since graduating from college in 2022.

Follow Tony Sartori @tony_sartori on Twitter/X.

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