The Cleveland Guardians host the Baltimore Orioles on April 17, 2026. First pitch from Progressive Field is scheduled for 6:10 p.m. ET. The game will be broadcast on MASN.
The Guardians are favored by -135 on the moneyline and by -1.5 on the run line. The Orioles are +110 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find our MLB picks and Orioles vs Guardians prediction below, as well as probable pitchers, weather report, and more.
Orioles vs Guardians Prediction
- Orioles vs Guardians Pick: Under 8 (-110)
Our Orioles vs Guardians best bet is Under 8 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Orioles vs Guardians Odds
| Orioles Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 8 -110o / -110u | +110 |
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +150 | 8 -110o / -110u | -135 |
- Orioles vs Guardians moneyline: Orioles +110, Guardians -135
- Orioles vs Guardians over/under: 8 (-110o / -110u)
- Orioles vs Guardians spread: Orioles +1.5 (-185), Guardians -1.5 (+150)
Orioles vs Guardians Probable Pitchers
| RHP Chris Bassitt (BAL) | Stat | RHP Tanner Bibee (CLE) |
|---|---|---|
| 0-2 | W-L | 0-2 |
| -0.1 | fWAR (FanGraphs) | 0.1 |
| 9.00/ 6.49 | ERA / xERA | 6.38 / 4.88 |
| 6.17 / 6.61 | FIP / xFIP | 5.02 / 3.61 |
| 2.36 | WHIP | 1.64 |
| -3.3 | K-BB% | 14.6 |
| 48.9 | GB% | 42.1 |
| 98 | Stuff+ | 100 |
| 93 | Location+ | 106 |
Orioles vs Guardians MLB Betting Preview
Our own Sean Zerillo projects a nice edge on the Under in this matchup's total.
While the consensus line sits around 8, Zerillo projects 7.27 runs for this game, representing a 3.7% edge against the market and a B- grade in our system.
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
Orioles vs Guardians Pick, Betting Analysis
These teams already produced a low-scoring game yesterday, with just six runs in the Guardians' 4-2 victory.
Baltimore ranks 10th in wRC+ so far, while Cleveland sits at 13th, but both offenses have suffered this year against right-handed pitchers, which is the case today.
The Orioles fall all the way to the 16th spot in wRC+ vs RHP, and the Guardians rank 19th.
While Chris Bassitt has not done well in this 2026 season for Baltimore, he should benefit from a more pitcher-friendly environment at Progressive Field in Cleveland, which ranks 21st on Baseball Savant's Park Factors Leaderboard.
Cleveland starter Tanner Bibee should bounce back after a horrible outing against the Braves, where he allowed eight runs and 11 hits in 4 and 2/3 innings. That start blew up his previously respectable stats.
Action PRO projects Bibee for 6.1 strikeouts against Baltimore.
Also, consider the fact that the Orioles' bullpen ranks fourth in WAR (1.0) and ninth in ERA (3.52) this season, making the Under a worthy play on Friday.
Pick: Under 8 (-110, BetMGM)
