Cubs vs Pirates Prediction, Pick, MLB Odds for Friday, July 24

The Chicago Cubs (57-45) and Pittsburgh Pirates (53-50) meet tonight, with the game set to start at 6:40 p.m. ET at PNC Park in Pittsburgh, Pa. The game will be broadcast live on SportsNet PT and can be traded on Polymarket.

The Pirates are slightly favored by traders, while the Cubs will be looking to pull off an upset.

Let's get into my Cubs vs Pirates predictions and picks.

Cubs vs Pirates Predictions, Odds

Cubs vs. Pirates Pick

Cubs vs Pirates Pick: Buy the Over and expect a high-scoring affair.

Cubs vs. Pirates Analysis

This system targets overs in games that begin in the late afternoon to early evening, in other words, what traders often refer to as "twilight spots."

These games exist in a temperature and lighting window that subtly elevates scoring conditions, particularly when both teams have a documented tendency to hit overs. Combined with home starters who may have below-average WHIPs, this setup identifies an edge before the public fully reacts. By isolating recent season trends and capitalizing on the transitional scoring environment, the model captures a high-expectation scoring spot that may be underpriced due to time-of-day bias or modest pitching projections.

Lifetime, this system has generated a 6% ROI, going 273-221-18 (55%).

Cubs vs. Pirates Prediction

Evan Abrams / Bet Labs – Twilight Totals (SEASON)

the game was played between 1/1/2016 and 1/1/2032

the game is played during the Regular season

betting on the Over

the visitor team's games have gone over the total between 45% and 60% of the time

the home team's games have gone over the total between 54% and 72% of the time

the home team's starting pitcher's WHIP is between 0.83 and 1.55

the game started between 16:00 and 18:59 ET

$3,234

WON

273-221-18

RECORD

55%

WIN%

View System

Chicago Cubs vs Pittsburgh Pirates Trade: Over