The St. Louis Cardinals host the Chicago Cubs on July 27, 2026. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT. The game will be broadcast on MARQ.
The Cubs are favored by -116 on the moneyline and by -1.5 on the run line. The Cardinals are -102 on the moneyline and +1.5 on the run line. The total is set at 9.5 runs.
Find my MLB picks and Cubs vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Cubs vs Cardinals Prediction
- Cubs vs Cardinals Pick: Under 10 (-117)
My Cubs vs Cardinals best bet is on the Under. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Cardinals Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +132 | 9.5 -115o / -105u | -116 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -160 | 9.5 -115o / -105u | -102 |
- Cubs vs Cardinals moneyline: Cubs -116, Cardinals -102
- Cubs vs Cardinals over/under: 9.5 (-115o / -105u)
- Cubs vs Cardinals spread: -1.5 (+132), +1.5 (-160)
Cubs vs Cardinals Probable Pitchers
| David Peterson (LHP) | Stat | Matthew Liberatore (LHP) |
|---|---|---|
| 5-7 | W-L | 5-7 |
| 0.8 | fWAR (FanGraphs) | 0.5 |
| 5.97/5.24 | ERA / xERA | 5.18/5.29 |
| 4.14/4.36 | FIP / xFIP | 4.83/4.31 |
| 8.9 | K-BB% | 13 |
| 47.2 | GB% | 35.7 |
| .326 | BABIP | .333 |
| 89 | Stuff+ | 98 |
| 100 | Location+ | 101 |
Cubs vs Cardinals MLB Betting Preview
Two under-appreciated lefties square off in this one. David Peterson goes for the Cubs. He is not very good as a starting pitcher, but he does have a habit of limiting homers. Peterson has given up just a .277 xwOBA to lefties. So he's very good against those hitters, of which the Cardinals have a few– against righties, it's worse, but the home run is usually not the problem.
Matt Liberatore is up-and-down, but he does flash some nice skills from time to time with his awesome curveball. The Cubs are on the road here coming off of a series in Pittsburgh. A lot of these Cubs are much better at home. They have a .779 OPS at home this year and a .720 mark on the road.
I like the spot for both pitchers. I wouldn't use them in fantasy leagues or in DFS, but when you see the O/U set at 10 here, that's where I know I'm going.
Pick: Under 10 (-117)
