The Washington Nationals host the Chicago White Sox on September 26, 2025. First pitch from Nationals Park is scheduled for 6:45 p.m. EDT; the game will be broadcast on MASN2.
Find my MLB betting preview and White Sox vs Nationals prediction below, as well as probable pitchers, betting trends, injury reports and more.
Our White Sox vs Nationals Prediction
- White Sox vs Nationals pick: Over 8.5
Our White Sox vs Nationals best bet is on the over total runs. Make sure to find the best odds by checking our live MLB odds page.
White Sox vs Nationals Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -185 | 8.5 -120o / 100u | +110 |
| Nationals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +155 | 8.5 -120o / 100u | -130 |
White Sox vs Nationals Projected Starting Pitchers
| RHP Yoendrys Gomez (CHW) | Stat | RHP Cade Cavalli (WSN) |
|---|---|---|
| 3-3 | W-L | 3-1 |
| 0.4 | fWAR (FanGraphs) | 0.4 |
| 4.92/5.18 | ERA /xERA | 4.23/4.13 |
| 4.75/4.95 | FIP / xFIP | 4.57/4.10 |
| 1.39 | WHIP | 1.43 |
| 10.3% | K-BB% | 10.1% |
| 35.5% | GB% | 54.5% |
| 99 | Stuff+ | 108 |
| 88 | Location+ | 94 |
White Sox vs Nationals Prediction, Betting Analysis
The Washington Nationals are -130 favorites on the moneyline for Friday’s series opener, while the Chicago White Sox sit at +110 to play spoiler. The total is set at 8.5 runs.
This is Game 1 of the series and the start of Chicago’s final set in what has been a nightmare season. The White Sox enter at 58-101, the second-worst mark in baseball ahead of only Colorado. Washington hasn’t fared much better, coming in at 65-94 and stuck at the bottom of the NL East.
Yoendrys Gomez gets the ball for the White Sox, while the Nationals counter with Cade Cavalli. Neither team has much at stake beyond playing out the string, which often leads to looser lineups, stretched bullpens, and higher-scoring outcomes.
That lines up with Evan Abrams’ Late Season Overs, Lower Totals system: in hitter-friendly or high-variance parks like Nationals Park, totals under 10.5 runs tend to get undervalued late in the year. Humid fall conditions in D.C. and inconsistent relief pitching with expanded rosters both contribute to games pushing over.
With this matchup featuring two struggling rotations and no playoff pressure, the setup points squarely toward runs.
Pick: Over 8.5 (-120, bet365)
White Sox vs Nationals Betting Trends
