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Reds vs Diamondbacks Prediction, Pick, MLB Odds for Friday, August 21

Reds vs Diamondbacks Prediction, Pick, MLB Odds for Friday, August 21 article feature image
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Jul 31, 2026; Cleveland, Ohio, USA; Arizona Diamondbacks right fielder Corbin Carroll (7) runs to third base during the eighth inning against the Cleveland Guardians at Progressive Field. Mandatory Credit: David Dermer-Imagn Images

The Arizona Diamondbacks host the Cincinnati Reds on August 21, 2026. First pitch from Chase Field is scheduled for 9:40 p.m. EDT. The game will be broadcast on CINR.

The Diamondbacks are favored by -145 on the moneyline and by -1.5 on the run line. The Reds are +127 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.

Find my MLB picks and Reds vs Diamondbacks prediction below, as well as probable pitchers, weather report, and more.


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Reds vs Diamondbacks Prediction

  • Reds vs Diamondbacks Pick: Corbin Carroll 1+ Doubles

My Reds vs Diamondbacks best bet is for Corbin Carroll to hit at least one double. Make sure to find the best odds by checking our live MLB odds page.


Reds vs Diamondbacks Odds

Reds Logo
August 21, 2026
9:40 p.m. EDT
CINR
Diamondbacks Logo
Reds Odds
SpreadTotalMoneyline
+1.5
+140
8.5
-100o / -116u
+127
Diamondbacks Odds
SpreadTotalMoneyline
-1.5
-170
8.5
-100o / -116u
-145
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Reds vs Diamondbacks moneyline: Reds +127, Diamondbacks -145
  • Reds vs Diamondbacks over/under: 8.5 (-100o / -116u)
  • Reds vs Diamondbacks spread: Diamondbacks -1.5 (+140 ), Reds +1.5 (-170)

Reds vs Diamondbacks Probable Pitchers

Nick Lodolo (LHP, CIN)StatEduardo Rodriguez (LHP, AZ)
3-2W-L12-4
0.3fWAR (FanGraphs)2.4
4.52 / 5.97ERA / xERA2.71 / 4.71
5.31 / 4.71FIP / xFIP3.83 / 4.42
8.9%K-BB%9.6%
43.8%GB%39.5%
.293BABIP.269
106Stuff+92
91Location+110

Reds vs Diamondbacks MLB Betting Preview

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Reds vs Diamondbacks Preview

The Diamondbacks enter Friday night seeking an offensive spark, and outfielder Corbin Carroll finds himself in an ideal spot to break off an extra-base hit.

Carroll has gone without an extra-base hit in four straight games, but his overall surface and quality-of-contact trends remain elite.

The star speedster leads Major League Baseball with 15 triples while racking up 26 doubles and 18 home runs on the season.

Over his past nine games, Carroll has stayed in peak rhythm, collecting 10 hits—including three doubles, two triples, and two homers.

Taking the mound for the Reds is Nick Lodolo, who brings alarming pitch-quality indicators into Phoenix. Lodolo's underlying metrics rank among the worst in the majors, holding a 5.98 xERA and a .369 xwOBA (both bottom 2% in MLB), an expected batting average (.287) in the bottom 4%, and a poor 8.9% barrel rate (26th percentile).

Lodolo relies heavily on a sinker and four-seam fastball split, but his four-seamer has been severely punished. According to Baseball Savant, Lodolo sits in the abysmal 11th percentile in Fastball Run Value.

While Carroll has only faced Lodolo three times in his career (going 1-for-2 with a HBP), Lodolo's struggles against left-handed power hitters who crush fastballs in the zone line up perfectly for Arizona's leadoff threat.


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Reds vs Diamondbacks Pick, Betting Analysis

Lodolo's underlying pitch metrics indicate severe vulnerability to hard contact, particularly when relying on his low-value fastball.

With Carroll swinging a hot bat over the past two weeks and taking aim at a home venue that favors extra-base hits into the gaps, Action Network's PRO projections give him a 7.1% edge to hit for extra bases.

Back Carroll to end his short extra-base hit drought and collect a two-bagger.

Pick: Corbin Carroll Over 0.5 Doubles (+370, FanDuel)


Reds vs Diamondbacks Weather


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