The Chicago Cubs host the Cincinnati Reds on June 1, 2025. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET; the game will be broadcast on Marquee and MLB.TV.
The Cubs enter as -160 favorites on the moneyline with the over/under sitting at 7.
Find my Reds vs Cubs prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Reds vs Cubs Prediction
- Reds vs Cubs Pick: TJ Friedl Over 0.5 Home Runs (+900)
My Cubs vs. Reds best bet is for Cincinnati's TJ Friedl to hit a home run. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cubs Odds
| Reds Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -160 | 7 -115o / -105u | +135 |
| Cubs Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +135 | 7 -115o / -105u | -160 |
Reds vs Cubs Projected Starting Pitchers
Reds vs Cubs MLB Betting Preview
For the Reds-Cubs matchup, my top MLB betting pick centers on TJ Friedl hitting a home run. Utilizing PRO Projections, we consistently track home run probabilities daily, and Friedl stands out as a strong candidate today.
Although Friedl isn’t typically recognized for his power-hitting abilities, he bats leadoff for the Reds and exhibits a smooth, efficient swing path that contributes to his home run potential.
This combination makes him an intriguing option, especially given the current betting odds.
Two days ago, our models rated Friedl high, with home run odds at about +1100, and he didn’t disappoint — he cleared the fences on the third pitch of the game.
Today, Friedl’s home run odds are set around +900, but our PRO Projections suggest a fair value closer to +614, indicating a clear betting edge.
Reds vs Cubs Pick, Betting Analysis
Through this season, Friedl has already hit four home runs — all of which came on the road.
While his home stadium ranks as one of the most hitter-friendly parks, this detail possibly leads to his home run value being underrated in today’s market.
For bettors looking for an edge, Friedl to homer offers a compelling opportunity in the Reds-Cubs showdown at 9-1, with the best odds at BetMGM as of writing.
Pick: TJ Friedl Over 0.5 Home Runs (+900)
