Guardians vs Yankees Pick, Odds and Betting Analysis

Guardians vs Yankees Pick, Odds and Betting Analysis article feature image
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Photo Credit: Ron Chenoy-Imagn Images. Pictured: Max Fried

The New York Yankees host the Cleveland Guardians on June 5, 2025. First pitch from Yankee Stadium is scheduled for 7:05 p.m. EDT; the game will be broadcast on MLB Network.

Find my MLB betting preview and Guardians vs Yankees pick below, as well as probable pitchers, betting trends, injury reports and more.

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My Guardians vs Yankees Pick

  • Guardians vs Yankees picks: Guardians vs Yankees Under 8.5 (-115 FanDuel)

My Guardians vs Yankees best bet is Under 8.5. Make sure to find the best odds by checking our live MLB odds page.


Guardians vs Yankees Pick

The Yankees will send their ace, Max Fried, to the mound tonight. Fried has posted a 1.69 ERA and a 0.96 WHIP through his first starts at Yankee Stadium and has held opponents to a .184 batting average in the process.

Fried is coming off of his worst start of the year against the Dodgers in Los Angeles, where he allowed eight hits, six earned runs and two home runs, while striking out just three across five innings. He’ll have an excellent chance to get back on track tonight against a Guardians team that, outside of Jose Ramirez, has struggled mightily against lefties this season, ranking 21st in OBP, 27th in SLG and 23rd in wRC+.

The past seven left-handed starting pitchers to face the Guardians have combined to allow just three earned runs across 47 2/3 innings (0.57 ERA). 

The Guardians will counter with young right-hander Slade Cecconi, who is making his fourth start for Cleveland since being acquired from Arizona in the offseason. While Cecconi’s numbers aren’t spotless, his strikeout rate gives him a chance to hang in against a Yankees lineup that, despite leading the majors in home runs, has shown signs of regression — including getting shut out by Cleveland just last night.

The Yankees’ goose egg last night triggered one of The Betting Insiders’ best systems for tonight’s game. 

System) Heavily Favored Home Teams Off of a Shutout (66% win rate, 28% ROI)

  • Home ML is between -175 and -400
  • Closing total between 8 and 10
  • Home team scored 0 runs in their previous game

Along with one of our top systems, we have two other great systems in-play. Check them out below!

System) In-conf, heavy home favs, both teams won L2/3, previous game went under (62% All-time, 71% this season)

  • Both teams W L2/3 games
  • Current total above 8, home team went U in prev game
  • Home ML is between -160 and -400
  • Game is in-conference

System) L5 years, Low BB SP’s, with low or avg K rates, good weather & high total (68% All-time, 30% ROI)

  • Both Home & Visiting SP’s have an SO rate of between 0.2 and 0.7
  • Both Home & Visiting SP’s have a Walk% of between .01 and .07
  • Wind direction is NOT out
  • Total is above 8.5

The Guardians have gotten length from their past few starters and should have most of their best bullpen arms available, including Cade Smith, Hunter Gaddis and Kolby Allard. 

With two capable bullpens behind these starters and cold bats on both sides, the ingredients are in place for a tightly contested, low-scoring affair. All signs point to value on Under 8.5 tonight in the Bronx.

Pick: Guardians vs Yankees U8.5 (-115 FanDuel)


Guardians vs. Yankees Odds

Guardians Logo
Thursday, Jun 5
7:05 p.m. ET
MLB Network
Yankees Logo
Guardians Odds
SpreadTotalMoneyline
+1.5
+110
8.5
-105o / -115u
+225
Yankees Odds
SpreadTotalMoneyline
-1.5
-130
8.5
-105o / -115u
-275
Odds via BetMGM. Get up-to-the-minute MLB odds here.
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Moneyline

I'm not betting the Guardians vs. Yankees moneyline.


Run Line (Spread)

I'm going to pass on the Guardians vs. Yankees run line.


Over/Under

As mentioned above, I'm betting the Guardians vs. Yankees under.


Guardians vs Yankees Betting Trends


Guardians vs Yankees starts at 7:05 p.m. EDT on Thursday, live from Yankee Stadium. The game will be broadcast on MLB Network.


Guardians vs Yankees Weather


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