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Twins vs White Sox Prediction, Pick, MLB Odds for Wednesday, May 27

Twins vs White Sox Prediction, Pick, MLB Odds for Wednesday, May 27 article feature image
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Photo Credit: Patrick Gorski-Imagn Images
Pictured: Austin Hays, Luisangel Acuna and Derek Hill celebrate

The Chicago White Sox host the Minnesota Twins on May 27, 2026. First pitch from Rate Field is scheduled for 7:40 p.m. EDT. The game will be broadcast on MNNT.

The White Sox are favored by -125 on the moneyline and by -1.5 on the run line. The Twins are +105 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and Twins vs White Sox prediction below, as well as probable pitchers, weather report, and more.


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Twins vs White Sox Prediction

  • Twins vs White Sox Pick: Luisangel Acuna Under 0.5 Hits (+125, DraftKings)

My Twins vs White Sox best bet is Acuna to record either one or no hits tonight. Make sure to find the best odds by checking our live MLB odds page.


Twins vs White Sox Odds

Twins Logo
May 27, 2026
7:40 p.m. EDT
MNNT
White Sox Logo
Twins Odds
SpreadTotalMoneyline
+1.5
+165
8
-100o / -120u
+105
White Sox Odds
SpreadTotalMoneyline
-1.5
-200
8
-100o / -120u
-125
Odds via DraftKings. Get up-to-the-minute MLB odds here.
DraftKings Logo
  • Twins vs White Sox moneyline: Twins +105, White Sox -125
  • Twins vs White Sox over/under: 8 (-100o / -120u)
  • Twins vs White Sox spread: White Sox -1.5 (+165 ), Twins +1.5 (-200)

Twins vs White Sox Probable Pitchers

Connor PrielippStatDavis Martin
27-28W-L27-27
0.3fWAR (FanGraphs)2.3
4.03 / 3.75ERA / xERA2.04 / 3.57
4.25 / 4.34FIP / xFIP2.30 / 2.85
14.6K-BB%13.1
37.2GB%44.3
.240BABIP.306
103Stuff+91
102Location+101

Twins vs White Sox MLB Betting Preview

Action PRO projects White Sox infielder Luisangel Acuna for 0.59 hits in his matchup against the Twins tonight, giving us a strong 11.2% edge against the market when compared to his current prop line of over/under 0.5, which is good enough to tag the Under with a B grade in our system.


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Twins vs White Sox Pick, Betting Analysis

Acuna has recorded 16 hits so far this season, but he has struggled to produce consistently at the plate. He has gone under this number in three of his last five games and in seven of his last 10 overall.

While Acuna's speed always gives him a chance to beat out an infield single, the value still sits on the under given his recent form and current market number.

Pick: Luisangel Acuna Under 0.5 Hits (+125, DraftKings)


Twins vs White Sox Weather


Get the latest coverage on MLB Weather.
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