We have three day games on Wednesday, including one at 12:35 PM ET between the Diamondbacks and Orioles.
Ryan Minion has a best bet for that game, while Tanner McGrath and Sean Zerillo have moneyline and over/under picks for two games later on in the day.
Check out our MLB picks and predictions below.
MLB Picks, Predictions
The team logos in the table below represent the matchups our MLB betting staff is targeting from today's slate of games. Click on the team logos for any of the matchups below to navigate to a specific bet discussed in this article.
| Game | Time (ET) | Pick |
|---|---|---|
  | 12:35 PM | |
  | 1:40 PM | |
  | 9:40 PM | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our MLB Odds page, which automatically surfaces the best lines for every game. | ||
Diamondbacks vs Orioles Player Prop Picks
By Ryan Minion
Though Orioles starting pitcher Kyle Bradish has a rather impressive history in previous at-bats against this Arizona lineup, it should come as no surprise that Diamondbacks second baseman Ketel Marte is the one hitter who has found success versus the Orioles’ righty.
While Marte has had just a few AB versus Bradish, the Dbacks three-time All-Star reached safely in all three plate-appearances, recording 2 hits, an RBI, and a walk.
Despite a largely impressive career thus far, Baltimore’s right-hander got Tommy John surgery in August of last year and has seemingly had substantial issues with his command in 2026 as a result.
Bradish's velocity has noticeably dipped since his return, specifically on his off-speed pitches (particularly his sinker), which could prove extremely problematic versus a hitter of Ketel Marte’s caliber.
While Marte has had a terrible start to the season as well, the D-Backs’ slugger is coming off three consecutive years in which he blasted over 25 homers. I fully expect things to turn around.
Ketel boasts incredible power on both sides of the plate, with elite bat speed. Ironically, Marte’s two favorite pitches to hit are a sinker and a four-seam fastball, also the two biggest weapons in Bradish’s arsenal.
Given his notably reduced velocity in 2026, I think Baltimore’s righty will once again be very susceptible to hard contact.
If Bradish falls behind in the count and leaves one of his favorite two pitches in the middle-up half of the zone, I could see Marte driving one deep on Wednesday.
Pick: Ketel Marte Over 1.5 Total Bases (-110 or Better)
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Red Sox vs Twins Over/Under Picks
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
This system isolates regular-season games where weather and market conditions align to suppress scoring.
Environmental filters play a key role: temperatures between 27–70 degrees, wind speeds of 2–13 mph, and wind direction either blowing in or across the field are all factors shown to reduce offensive output.
The system bets the under when market expectations, game context, and weather patterns point to lower-than-expected run production — consistently exploiting soft totals inflated by public bias or overlooked conditions.
The weather should be very pitcher-friendly in Minnesota on Wednesday afternoon, with temperatures in the mid-50s and winds blowing directly in toward home plate. BallParkPal projects a -13% home run factor for the game.
I'm also very high on Boston starting pitcher Connelly Early, who has some nasty secondary stuff.
I'm also not very high on Boston's lineup, which is a mess as currently constructed (88 wRC+).
Want more Bet Labs systems? Download the Action Network App and sign up for an Action PRO subscription here:
Pick: Under 8 (-110 or Better)
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Mariners vs Padres Moneyline Picks
By Sean Zerillo
Both Emerson Hancock and Randy Vasquez may be on the verge of breakout campaigns, but it's Hancock — the former No. 6 overall pick in the 2020 draft — who has the higher ceiling.
For his career, Hancock has performed as a replacement-level starter (5.17 xERA, 4.68 xFIP, 9.4% K-BB%) with a below-average arsenal (91 Stuff+, 4.46 botERA). Still, he appears to have found himself this offseason (2.41 xERA, 2.87 xFIP, 25.8% K-BB%, 2.98 botERA) by changing his arm angle and revamping his pitch mix — putting away his changeup (down from >20% to 3.5%) and sinker (down from 32% to 16%) in favor of more four-seam fastballs (40%, career high) sliders (up from 17% to 27%) and his new cutter (12.7%).
Vasquez (career 5.48 xERA, 5.12 xFIP, 7.2% K-BB%) has also seen an uptick in performance (4.25 xERA, 3.11 xFIP, 21.7% K-BB%) but without big corresponding changes in his Stuff+ rating (94 to 98) or botERA (3.92 to 3.34). He has modified his pitch mix, increasing his four-seam fastball usage (up from 21% to 33%) and throwing it harder (948 mph) than ever before. And his swinging strike rate has more than doubled in a small sample this season, from 7.6% career to 14.3%.
I prefer the Mariners' offense in this matchup; every bat in their order projects as above-average against right-handed pitching (projected 118 wRC+), whereas the Padres have a couple of below-average hitters and project about seven points worse (111 wRC+) in the aggregate.
Seattle also has the better bullpen, too; both Jason Adam and Adrian Morejon have worked three times in five days, and aside from Miller and Morejon, Seattle has five of the top seven bullpen arms in this matchup (Jason Adam is just behind Eduard Bazardo at a 3.73 to 3.74 weighted FIP).
My edge relative to the market for Wednesday isn't as large as it was on Tuesday, so my stake is slightly reduced.
Still, you can bet the Mariners to -110.
Check out all of Zerillo's MLB bets for Tuesday here:
Pick: Mariners ML (-110 or Better)
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