The Minnesota Twins host the New York Yankees on September 16, 2026. First pitch from Target Field is scheduled for 1:40 p.m. EDT. The game will be broadcast on MNNT.
The Yankees are favored by -148 on the moneyline and by -1.5 on the run line. The Twins are +123 on the moneyline and +1.5 on the run line. The total is set at 8 runs.
Find my MLB picks and Yankees vs Twins prediction below, as well as probable pitchers, weather report, and more.
Yankees vs Twins Prediction
- Yankees vs Twins Pick: Ben Rice Over 2.5 HRR (+138) | Yankees ML (-148)
My Yankees vs Twins best bets are on Ben Rice to record over 2.5 Hits + Runs + RBIs and New York to win outright. Make sure to find the best odds by checking our live MLB odds page and download the Action Network app for more picks and analysis.
Yankees vs Twins Odds
| Yankees Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +114 | 8 -108o / -112u | -148 |
| Twins Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -137 | 8 -108o / -112u | +123 |
- Yankees vs Twins moneyline: Yankees -148, Twins +123
- Yankees vs Twins over/under: 8 (-108o / -112u)
- Yankees vs Twins spread: Yankees -1.5 (+114), Twins +1.5 (-137)
Yankees vs Twins Probable Pitchers
| Carlos Rodon (LHP, NYY) | Stat | Zebby Matthews (RHP, MIN) |
|---|---|---|
| 6-3 | W-L | 9-10 |
| 1.4 | fWAR (FanGraphs) | 0.3 |
| 2.94/3.79 | ERA / xERA | 4.98/4.64 |
| 3.57/4.12 | FIP / xFIP | 4.98/4.22 |
| 14.8% | K-BB% | 12.4% |
| 36.2% | GB% | 42.7% |
| .225 | BABIP | .273 |
| 107 | Stuff+ | 95 |
| 88 | Location+ | 101 |
Yankees vs Twins MLB Betting Preview
The Twins and Yankees will square off on Wednesday afternoon in another spot where I heavily favor targeting player prop markets.
33-year-old veteran left-hander Carlos Rodon will get the start for New York, while righty Zebby Matthews will take the mound for the Twins.
In what has been an up-and-down 2026 campaign for Minnesota’s right-hander, with Matthews currently posting a 4.98 ERA so far, I expect this to be another tough challenge against a red-hot Yankee lineup.
In this case, I expect the Yankees’ lefty slugger Ben Rice to have a monster day at the plate versus the Twins’ 26-year-old.
In eight previous encounters between the two, New York’s 27-year-old has recorded four hits – two of which were for extra bases, with a double and a home run.
The Yankees’ youngster put on a ton of muscle in the offseason and has quickly established himself as one of baseball’s premier power hitters — ranking seventh in all of baseball with 38 HRs in 2026 thus far.
Matthews has struggled to keep the ball in the yard for most of the season, allowing 23 homers in fewer than 120 frames on the mound.
I expect this to be a highly favorable matchup for Rice given his remarkably impressive pull-heavy left-handed power bat.
New York’s Designated Hitter is also on an absolute tear right now, so he enters Wednesday’s contest in phenomenal form.
That said, I favor backing Rice to exceed an alternate 2.5 HRR total as my primary betting angle ahead of Wednesday’s American League showdown.
As a secondary wager, I'm willing to take a shot on the Yankees moneyline as well given their far superior lineup and a rather significant edge on the mound on Wednesday afternoon.
Picks: Ben Rice Over 2.5 HRR (+138) | Yankees ML (-148)
