The Cincinnati Reds host the San Diego Padres on June 27, 2025. First pitch from Great American Ball Park is scheduled for 7:10 p.m. EDT; the game will be broadcast on SDPA.
San Diego's Dylan Cease will oppose Cincinnati's Nick Martinez in the opener of this three-game series.
Find our MLB betting preview and Padres vs Reds prediction below, as well as probable pitchers, betting trends, injury reports and more.
Our Padres vs Reds Prediction
- Padres vs Reds picks: Padres moneyline (-135, BetMGM)
Our Padres vs Reds best bet is on the Padres moneyline. Make sure to find the best odds by checking our live MLB odds page.
Padres vs Reds Odds
| Padres Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +125 | 9 -120o / 100u | -135 |
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -150 | 9 -120o / 100u | +115 |
Padres vs Reds Projected Starting Pitchers
| RHP Dylan Cease (SD) | Stat | RHP Nick Martinez (CIN) |
|---|---|---|
| 3-6 | W-L | 4-8 |
| 2.2 | fWAR (FanGraphs) | 1.1 |
| 4.43/3.47 | ERA /xERA | 4.40/4.27 |
| 3.01/3.32 | FIP / xFIP | 4.38/4.39 |
| 1.29 | WHIP | 1.23 |
| 20.4 | K-BB% | 12.4 |
| 37.2 | GB% | 35.2 |
| 108 | Stuff+ | 92 |
| 100 | Location+ | 108 |
Padres vs Reds Preview
San Diego won the past two series against the Kansas City Royals and Washington Nationals, and will look to add a third straight, now on the road, against the Reds.
They have mostly had to rely on their pitching staff. In both of those series, the Padres won every game where their starter pitched at least into the fifth inning, so that will again be the task for Dylan Cease tonight.
Cease is coming off a great performance against the Royals. He gave up only one run and three hits, with four strikeouts, over 6 2/3 innings last Saturday.
Meanwhile, Nick Martinez is briefly returning to Cincinnati's rotation after three relief appearances, though he will probably go back to the bullpen.
Luis Arraez is on a 12-game hitting streak and has a .400 average and a .800 OPS over the past seven days.
The Padres hit Martinez very well, with Arraez (.500), Martin Maldonado (.400), Xander Bogaerts (.385), Elias Diaz (.429), Tyler Wade (.500), Manny Machado (.364) and Fernando Tatis Jr. (.400) all batting over .350 against him.
Padres vs Reds Prediction, Betting Analysis
The system titled "Road Flip Bet" targets regular-season MLB matchups where a team shifts from playing at home to playing on the road in a non-division game and becomes a slight road favorite.
It looks for teams that were at home in their last game but now travel, while still holding market respect, indicated by a short favorite price between -140 and -120.
By focusing on non-division matchups, the system removes familiarity edges and isolates travel spots where the market's confidence in the team's quality outweighs any concerns about the venue change.
These situations often highlight teams in rhythm, carrying momentum from a home stand into a new series while catching the opponent off guard without the added tension of a division rivalry.
By backing these mild road favorites during the regular season, the system leverages travel transitions where team quality and market pricing align, capitalizing on the confidence that the team can handle the shift in environment without a drop in performance.
Pick: Padres Moneyline (-135, BetMGM)
Padres vs Reds Betting Trends
Padres vs Reds Weather
