The San Francisco Giants host the San Diego Padres on Thursday, June 5, 2025. First pitch from Oracle Park is scheduled for 3:45 p.m. ET; the game will be broadcast on SDPA and MLB.TV.
The Giants enter as -115 favorites on the moneyline with the over/under sitting at 7.5.
Find my Padres vs Giants prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
San Diego Padres vs San Francisco Giants Prediction, Picks
- Padres vs Giants Pick: Under 7.5
My Giants vs. Padres best bet is on the under. Make sure to find the best odds by checking our live MLB odds page.
Padres vs Giants Odds, Line, Spread
| Padres Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +164 | 7.5 +105o / -125u | -105 |
| Giants Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -198 | 7.5 +105o / -125u | -115 |
Padres vs Giants Projected Pitchers
| Dylan Cease (SD) | Stat | Robbie Ray (SF) |
|---|---|---|
| 1-4 | W-L | 7-1 |
| 1.4 | fWAR (FanGraphs) | 1.5 |
| 4.66 / 3.64 | ERA /xERA | 2.43 / 2.82 |
| 3.29 / 3.19 | FIP / xFIP | 3.06 / 3.71 |
| 1.29 | WHIP | 1.11 |
| 21.2 | K-BB% | 17.1 |
| 37.1 | GB% | 41.2 |
| 107 | Stuff+ | 99 |
| 103 | Location+ | 92 |
Padres vs Giants Pick, Best Bets
According to Evan Abrams' system "Contrarian Unders for Winning Teams, Later in Series," this play is a prime target on Thursday in the MLB.
This system lights up when it's game 2-4 of a series between two winning clubs when the public under percentage sits between 0% and 35%.
This is the fourth and final game of this series between NL West rivals and the two squads sit second and third, respectively, in the division.
What makes this play even better is the fact that the system has a 5.8% ROI and it's +$14,494 since inception.
It's also backed by another system that's lighting up for this under: "Contrarian Unders for Winning Teams." With a 4.3% ROI, it represents another reason to lock in this pick.
Pick: Under 7.5
