The Chicago Cubs host the San Francisco Giants on May 6, 2025. First pitch from Wrigley Field is scheduled for 7:40 p.m. ET; the game will be broadcast on NBCS-BA and MLB.TV.
The Cubs enter as -150 favorites on the moneyline with the over/under sitting at 8.
Find my Giants vs Cubs predictions and MLB same-game parlay picks below.
San Francisco Giants vs Chicago Cubs Prediction, Picks
- Cubs ML
- Verlander Over 16.5 Outs
Parlay Odds: +200 (Fanatics)
Giants vs Cubs Odds, Spread, Lines
| Giants Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -160 | 8 -115o / -105u | +125 |
| Cubs Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +135 | 8 -115o / -105u | -150 |
Giants vs Cubs Projected Pitchers
| RHP Justin Verlander (SFG) | Stat | RHP Colin Rea (CHC) |
|---|---|---|
| 0-2 | W-L | 2-0 |
| 0.5 | fWAR (FanGraphs) | 0.7 |
| 4.38 / 3.72 | ERA /xERA | 1.46 / 3.52 |
| 4.14 / 4.31 | FIP / xFIP | 2.50 / 3.75 |
| 1.30 | WHIP | 1.05 |
| 12.1% | K-BB% | 16.2% |
| 37.5% | GB% | 35.6% |
| 108 | Stuff+ | 97 |
| 94 | Location+ | 95 |
Giants vs Cubs MLB Parlay
Moneyline Pick: Cubs ML
In Tuesday's matchup, I'm backing the Cubs to win against the Giants in a small negative correlation parlay.
The Cubs are on top of the NL Central and will look to continue their good spell. They also have the pitching advantage tonight, as Colin Rea is 2-0 with an outstanding 1.46 ERA.
With a better pitcher and home advantage, this is a clear pick.
Giants Player Prop: Justin Verlander Over 16.5 Outs
The other parlay piece will be Justin Verlander's Outs prop.
He's eclipsed this prop line in five consecutive starts despite not earning a single win.
His ERA is relatively high (4.38), but the Giants trust him and tend to leave him out on the mound for a while.
Giants vs Cubs Same-Game Parlay
- Cubs ML
- Verlander Over 16.5 Outs
Parlay odds: +200 (Fanatics)
