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Giants vs Royals Prediction, Pick, MLB Odds for Wednesday, July 22

Giants vs Royals Prediction, Pick, MLB Odds for Wednesday, July 22 article feature image
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Stephen Brashear-Imagn Images. Pictured: Giants SP Landen Roupp

The Kansas City Royals host the San Francisco Giants on July 22, 2026. First pitch from Kauffman Stadium is scheduled for 2:10 p.m. ET. The game will be broadcast on NBCS-BA.

The Giants are favored by -120 on the moneyline and by -1.5 on the run line. The Royals are +102 on the moneyline and +1.5 on the run line. The total is set at 9 runs.

Find my MLB picks and Giants vs Royals prediction below, as well as probable pitchers, weather report, and more.


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Giants vs Royals Prediction

  • Giants vs Royals Pick: Vinnie Pasquantino Over 1.5 HRR


Giants vs Royals Odds

Giants Logo
Wednesday, Jul 22
2:10 p.m. ET
NBCS-BA
Royals Logo
Giants Odds
SpreadTotalMoneyline
-1.5
+138
9
-110o / -110u
-120
Royals Odds
SpreadTotalMoneyline
+1.5
-166
9
-110o / -110u
+102
Odds via FanDuel. Get up-to-the-minute MLB odds here.
FanDuel Logo
  • Giants vs Royals moneyline: Giants -120, Royals -102
  • Giants vs Royals over/under: 9 (-110o / -110u)
  • Giants vs Royals spread: Giants -1.5 (+138), Royals +1.5 (-166)

Giants vs Royals Probable Pitchers

Landen Roupp (RHP, SF)StatSeth Lugo (RHP, KC)
7-8W-L3-6
2.2fWAR (FanGraphs)1.1
3.98 / 3.40ERA / xERA4.39 / 5.52
3.32 / 3.74FIP / xFIP4.34 / 4.49
14.0K-BB%11.2
50.2GB%39.8
.292BABIP.319
99Stuff+89
107Location+105

Giants vs Royals MLB Betting Preview, Prediction

Landen Roupp of the Giants squares off against Royals’ hurler Seth Lugo, and both have been extremely volatile prior to the All-Star break.

Per BARTOLO, Roupp heavily relies on his sinker more than any other pitch in his arsenal, throwing his primary pitch at a 35.8% clip, obliterating any of his other offerings.

Despite his clear comfort level throwing his sinker, that pitch has been extremely inefficient thus far, with opposing hitters recording a subpar .365 xwOBA to go along with both extremely low strikeout and whiff rates of 10% and 13%, respectively.

Meanwhile, Vinnie Pasquantino has always been good at hitting sinkers, posting a +4 Run Value against the pitch since the start of last season.

Picks: Vinnie Pasquantino Over 1.5 HRR


Giants vs Royals Weather


Get the latest coverage on MLB Weather.
Author Profile
About the Author

Ryan graduated from Providence College in 2016 with Bachelor Degrees in Business Economics & Mathematics. It was at Providence where Ryan really first found his passion for sports betting. For a lifelong sports fan with a knack for statistical analysis, he was instantly drawn to the fundamentals of the industry, specifically how sports betting markets functioned and fluctuated. In what primarily started as a recreational hobby, Ryan began studying the ins-and-outs of sports betting markets on a daily basis. He took to Twitter (now X), where he amassed a following for writing a sports betting blog that provided statistical analysis behind his wagers. In spite of seeking employment opportunities elsewhere post graduation, Ryan continued to follow his passion for the statistical analysis of sports betting wagers, eventually deciding to pursue a career in the sports betting industry.

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