The St. Louis Cardinals host the San Francisco Giants on September 14, 2026. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT. The game will be broadcast on CARD.
The Cardinals are favored by -145 on the moneyline and by -1.5 on the run line. The Giants are +118 on the moneyline and +1.5 on the run line. The total is set at 7.5 runs.
Find my MLB picks and Giants vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Giants vs Cardinals Prediction
- Giants vs Cardinals Pick: Under 8 (-115 at BetMGM | Play to -120)
My Giants vs Cardinals best bet is on the under total runs. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.
Giants vs Cardinals Odds
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -190 | 8 100o / -120u | +118 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +154 | 8 100o / -120u | -145 |
- Giants vs Cardinals moneyline: Giants +118, Cardinals -145
- Giants vs Cardinals over/under: 7.5 (+100o / -120u)
- Giants vs Cardinals spread: Cardinals -1.5 (+154), Giants +1.5 (-190)
Giants vs Cardinals Probable Pitchers
| Landen Roupp (RHP, SFG) | Stat | Quinn Mathews (LHP, STL) |
|---|---|---|
| 9-13 | W-L | 1-3 |
| 2.4 | fWAR (FanGraphs) | 0.5 |
| 4.00/3.73 | ERA / xERA | 4.11/3.54 |
| 3.74/4.22 | FIP / xFIP | 4.02/4.52 |
| 10.5% | K-BB% | 10.2% |
| 49.3% | GB% | 39.1% |
| .268 | BABIP | .319 |
| 98 | Stuff+ | 96 |
| 104 | Location+ | 102 |
Giants vs Cardinals MLB Betting Preview, Expert Pick
A good pitching duel should be in store, with the Giants' Landen Roupp slated to face the Cardinals' Quinn Mathews.
Roupp excels at limiting hard contact, given that he ranks in the 94th percentile in average exit velocity, 89th percentile in barrel rate and 97th percentile in hard-hit rate.
Meanwhile, Mathews has found his footing after a shaky start to his rookie campaign. He's allowed two or fewer runs in each of his past three starts, posting a 2.16 ERA and 1.26 WHIP over that stretch.
The most recent of those outings came against San Francisco, a game in which Mathews allowed just two runs in six innings of work. There were only three total runs scored in that contest.
His underlying metrics suggest that this success is likely to continue. If he qualified, Mathews would rank in the top half of the league in xERA, xBA, average exit velocity and barrel rate.
Pick: Under 8 (-115 at BetMGM | Play to -120)
