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Mariners vs Angels Prediction, Pick, MLB Odds for Wednesday, September 16

Mariners vs Angels Prediction, Pick, MLB Odds for Wednesday, September 16 article feature image
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Photo Credit: Dennis Lee-Imagn Images
Pictured: Randy Arozarena hits a two-run home run

The Los Angeles Angels host the Seattle Mariners on September 16, 2026. First pitch from Angel Stadium is scheduled for 9:38 p.m. EDT. The game will be broadcast on ABTV.

The Mariners are favored by -140 on the moneyline and by -1.5 on the run line. The Angels are +115 on the moneyline and +1.5 on the run line. The total is set at 8 runs.

Find my MLB picks and Mariners vs Angels prediction below, as well as probable pitchers, weather report, and more.


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Mariners vs Angels Prediction

  • Mariners vs Angels Pick: Randy Arozarena Over 0.5 Home Runs (+450)

My Mariners vs Angels best bet is on Arozarena to record 1+ home runs. Make sure to find the best odds by checking our live MLB odds page.


Mariners vs Angels Odds

Mariners Logo
September 16, 2026
9:38 p.m. EDT
ABTV
Angels Logo
Mariners Odds
SpreadTotalMoneyline
-1.5
-150
8
-105o / -112u
-140
Angels Odds
SpreadTotalMoneyline
+1.5
+121
8
-105o / -112u
+115
Odds via FanDuel. Get up-to-the-minute MLB odds here.
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  • Mariners vs Angels moneyline: Mariners -140, Angels +115
  • Mariners vs Angels over/under: 8 (-105o / -112u)
  • Mariners vs Angels spread: Mariners -1.5 (+121), Angels +1.5 (-150)

Mariners vs Angels Probable Pitchers

George KirbyStatYusei Kikuchi
9-11W-L1-5
2.5fWAR (FanGraphs)0.6
4.25 / 4.14ERA / xERA4.75 / 5
3.84 / 3.90FIP / xFIP4.19 / 4.19
14.2K-BB%13.1
43.9GB%38.9
.334BABIP.327
101Stuff+98
112Location+101

Mariners vs Angels MLB Betting Preview

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Mariners vs Angels Pick, Betting Analysis

This is a great spot, and these odds are a bit too high. Yusei Kikuchi hasn't been horrible at suppressing righty power this season, but historically, he's been a matchup that is well above average for righty power. Randy Arozarena has been one of the best HR hitters in the league since the All-Star Break, and I have the true odds here around +400.

Pick: Randy Arozarena Over 0.5 Home Runs (+450)


Mariners vs Angels Weather


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About the Author
Grant NeifferVerified Action Expert

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