The Arizona Diamondbacks (48-50) host the St. Louis Cardinals (51-47) on Saturday, July 19, 2025. First pitch from Chase Field is scheduled for 7:15 p.m. ET; the game will be broadcast on FOX.
Find a Cardinals vs Diamondbacks prediction for Saturday in our MLB betting preview below.
Cardinals vs Diamondbacks Prediction
- Cardinals vs Diamondbacks pick: Cardinals Moneyline (-120)
My Cardinals vs Diamondbacks best bet is on the St.Louis Moneyline. Make sure to find the best odds by checking our live MLB odds page.
Cardinals vs Diamondbacks Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +137 | 8.5 -110o / -111u | -120 |
| Diamondbacks Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -166 | 8.5 -110o / -111u | -101 |
Cardinals vs Diamondbacks Projected Starting Pitchers
| RHP Sonny Gray (STL) | Stat | RHP Ryne Nelson (ARI) |
|---|---|---|
| 9-3 | W-L | 5-2 |
| 3.0 | fWAR (FanGraphs) | 0.7 |
| 3.50/ 3.55 | ERA /xERA | 3.68/ 4.20 |
| 2.71/ 2.87 | FIP / xFIP | 3.82/ 4.04 |
| 1.08 | WHIP | 1.07 |
| 22.9% | K-BB% | 12.7% |
| 41.4% | GB% | 41.9% |
| 99 | Stuff+ | 102 |
| 100 | Location+ | 103 |
Cardinals vs Diamondbacks Prediction, Betting Analysis
Sonny Gray is expected to get the start for the Cardinals and Ryne Nelson for the Diamondbacks. Nelson is 3-0 with a 2.43 ERA in his last six starts; the Diamondbacks are 5-1 over that stretch.
However, the Cardinals have an ace up their sleeve in Nolan Arenado. The St. Louis third baseman, who has 32 career home runs against the D-backs, will look to become Arizona's executioner again.
Evan Abrams' Road Tilt in the Dead Heat system targets MLB regular-season games where two evenly matched teams — based on win percentage — meet in a non-division setting, and one is quietly priced as a modest road favorite.
When there's no clear performance gap, but the market still tilts slightly toward the road team, it suggests underlying confidence from oddsmakers that may not be reflected in public perception.
Pick: Cardinals ML (-120)
