Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026
Louisville at Michigan St
6:45 pm • CBSLouisville at Michigan St Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Louisville 23-10 | +3.5 | +4.5-110 | o151.5-105 | +165 |
 Michigan St 25-7 | u150.5 | -4.5-110 | u151.5-115 | -200 |
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Louisville vs. Michigan St Expert Picks
Babs .
Last 30d: 97-76-0 (+10.5u)
Under 151.5-110
1u
John Lanfranca
Last 30d: 6-2-0 (+3.8u)
MSU -4-110
0.55u
Babs .
Last 30d: 97-76-0 (+10.5u)
MSU -4.5-110
1u
Brandon Kravitz
Last 30d: 60-84-0 (-13.3u)
MSU -4.5-105
0.53u
Mike McNamara
Last 30d: 99-125-2 (+4.1u)
MSU -178
0.8u
Doug Ziefel
Last 30d: 130-143-3 (-10.8u)
LOU +170
0.29u
LOU +4.5-110
0.55u
Nick Giffen
Last 30d: 30-65-0 (+1.2u)
LOU +170
0.4u
Giffen Guide to March Madness: https://www.actionnetwork.com/ncaab/nick-giffens-moneyline-rollover-picks-2026-guide-march-madness
Louisville vs. Michigan St Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Louisville vs. Michigan St Public Betting Percentages
Betting Trends
- Michigan St are 3-2 in their last 5 games.
- Michigan St are 3-2 in their last 5 games against the spread
- Michigan St are 7-4 in their road games against the spread
- The totals have gone OVER in 4 of Michigan St' last 5 games
- The totals have gone OVER in 9 of Michigan St' 21 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 16-16 | 9-12 | 7-4 | 12-13 | 4-2 |
| 15-18 | 9-9 | 6-9 | 11-13 | 1-3 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 15-17 | 9-12 | 6-5 | 12-13 | 3-3 |
| 12-21 | 5-13 | 7-8 | 9-15 | 1-3 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 25-7 | N/A | N/A | 22-3 | 2-4 |
| 23-10 | N/A | N/A | 17-7 | 1-3 |
Last 5 Matchups
Louisville vs. Michigan St Injury Updates
Louisville Injuries
- Mikel BrownG
Brown is questionable with back
Questionable
Michigan St Injuries
- Kaleb GlennF
Glenn is out for season with knee
Out for Season
- Divine UgochukwuG
Ugochukwu is out for season with foot
Out for Season
Team Stats
28-61 (46%)
Field Goals
27-58 (47%)
15-20 (75%)
Free Throws
16-21 (76%)
11-32 (34%)
3P
7-21 (33%)
36.12
Rebounds
36.91
17.1
Assists
18.5
11.33
Turnovers
10.81
6.88
Steals
5.13
3.33
Blocks
4.09
18.42
Fouls
16.28
Louisville vs. Michigan St Odds Comparison
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Louisville at Michigan St Team Totals
MatchupOverUnder | ||
|---|---|---|
Louisville 23-10 | N/A | N/A |
Michigan St 25-7 | N/A | N/A |