Louisville vs Michigan State Odds, Picks & Predictions - March 21, 2026

Louisville at Michigan St

6:48 pm • CBS

Louisville Cardinals

0-0

69 - 77

Michigan State Spartans

0-0

MatchupOpenSpreadTotalMoneyline
Louisville 0-0	+3.5	+5.5-111	o151.5-110	+200
Michigan St 0-0	u150.5	-5.5-109	u151.5-110	-245

Saturday 6:48 p.m.

March 21, 2026

KeyBank CenterBuffalo

LOU +4.5-105

LOU +5.5-110

1.1u

LOU +9.5 (Live)-110

0.14u

Good time to get in. 55-15 3P% after Cowell foul trouble. 7+ good

MSU -178

0.45u

LOU +5-110

0.55u

MSU u78.5-115

0.5u

LOU +5.5-115

0.58u

LOU +170

0.29u

LOU +4.5-110

0.55u

LOU +5.5-115

0.29u

Under 152-110

R.Conwell o19.5 Pts-108

@sushibet

LOU +3.5+117

MSU -4.5-105

0.5u

R.Conwell o19.5 Pts+100

LOU +5.5-115

0.58u

#Tailing @The_Oddsmaker

Under 151.5-110

0.91u

MSU -4.5-110

1.36u

LOU +170

0.4u

Giffen Guide to March Madness: https://www.actionnetwork.com/ncaab/nick-giffens-moneyline-rollover-picks-2026-guide-march-madness

LOU +5.5-115

0.58u

Tailing @The_Oddsmaker

LOU +5.5-110

Gotta do it

MSU -2.5 (1H)-110

LOU +9.5 (Live)-115

0.5u

MSU -4.5-110

0.91u

Under 152.5-115

1.09u

Under 71 (1H)-105

$100.00

Supposed to be to win $50

Under 151.5-110

0.91u

MSU -4.5-110

0.91u

MSU -4.5-110

2.73u

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NCAAB Public Betting

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Michigan St	N/A	N/A	N/A	N/A	N/A
Louisville	N/A	N/A	N/A	N/A	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Michigan St	N/A	N/A	N/A	N/A	N/A
Louisville	N/A	N/A	N/A	N/A	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Michigan St	N/A	N/A	N/A	N/A	N/A
Louisville	N/A	N/A	N/A	N/A	N/A

date	opponent	score	spread	over/under	moneyline
Mar 19th	NDSU	W 92-67	-16.5 W	O 144.5	MSU -1650
Mar 14th	UCLA	L 84-88	-5.5 L	O 141.5	UCLA -235
Mar 8th	@MICH	L 80-90	+10.5 W	O 152.5	MICH +412
Mar 6th	RUTG	W 91-87	-19.5 L	O 142.5	MSU -3743
Mar 1st	@IND	W 77-64	-3 W	U 144.5	MSU -170

Louisville

Michigan St

26-63 (41%)

Field Goals

26-55 (47%)

4-6 (67%)

Free Throws

14-19 (74%)

13-37 (35%)

11-26 (42%)

Rebounds

Assists

Turnovers

Steals

Blocks

Fouls

Could not load odds

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MatchupOverUnder
Louisville 0-0	N/A	N/A
Michigan St 0-0	N/A	N/A

Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026

Louisville at Michigan St

Louisville Cardinals

Michigan State Spartans

Louisville at Michigan St Odds

Spread, Total, Moneyline

Louisville vs. Michigan St Previews & Analysis

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Model-Based Total Highlights Our Saturday NCAA Tourney Best Bets

McGrath's Projected Scores for Every NCAA Tournament Second-Round Matchup

Prop Odds Comparison

Line Movement Tracker

Louisville vs. Michigan St Public Betting Percentages

Louisville

Public

Michigan St

Bets%

Money%

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Louisville vs. Michigan St Odds Comparison

Louisville at Michigan St Team Totals