Owls vs. Panthers Odds & Betting Predictions - October 21, 2025

Owls at Panthers

11:00 pm • ESPN2
45 - 26

Owls at Panthers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Owls
10-4
+1.5
+1.5-115
o48.5-115
-155
Panthers
7-6
u49.5
-1.5-105
u48.5-105
+130
location pinTuesday 11:00 p.m.
October 21, 2025
Pitbull StadiumMiami
Owls vs. Panthers Expert Picks
Mike Calabrese
Mike Calabrese
Last 30d: 51-44-3 (+9.0u)
FIU +17.5 (Live)-105
1u
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 32-24-0 (+5.6u)
FIU +3-105
0.5u
John Feltman
John Feltman
Last 30d: 76-76-2 (-11.0u)
FIU +3-110
3.3u
Stuck 🚨
Stuck 🚨
Last 30d: 57-59-7 (-0.8u)
FIU +3-107
0.3u
Forgot to log this earlier in week from pod. Can look live too
Mike Calabrese
Mike Calabrese
Last 30d: 51-44-3 (+9.0u)
KENN -2.5-125
1u
🔑 1 banged up?
Wags Wins
Wags Wins
Last 30d: 310-336-7 (-33.4u)
Over 48.5-120
1.25u
Scott Rickenbach
Scott Rickenbach
Last 30d: 93-107-1 (-25.5u)
KENN -155
0.65u
Duck
Duck
Last 30d: 85-70-0 (+2.3u)
FIU +130
0.3u
Roger Goodell
Roger Goodell
Last 30d: 21-27-0 (-7.8u)
FIU +130
0.5u
💰🦡 Jake
💰🦡 Jake
Last 30d: 73-94-4 (-25.3u)
Under 24.5 (1H)-113
1.13u
Anders
Anders
Last 30d: 15-15-0 (+0.5u)
FIU +3.5-115
1.15u
Moneyline Hacks
Moneyline Hacks
Last 30d: 134-116-0 (+39.8u)
KENN -158
0.63u
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Duck
Duck
Last 30d: 85-70-0 (+2.3u)
FIU +3.5-113
1.13u
Action article write up coming.
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 154-147-1 (+1.3u)
KENN -115
0.78u
Collin Wilson
Collin Wilson
Last 30d: 21-13-3 (+7.9u)
FIU +2.5-118
1.18u
Project FIU -2; Panthers defense should dominate in passing downs, also top 30 defensive finishing drives. FIU rush explosives advantage over Kennesaw D

Owls vs. Panthers Previews & Analysis

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See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Owls vs. Panthers Public Betting Percentages

Away Logo

Owls

Public

24%

Bets%

76%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Panthers
8-44-24-24-13-3
Owls
9-45-14-36-33-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Panthers
6-63-33-32-34-2
Owls
6-72-44-35-41-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Panthers
7-5N/AN/A4-13-3
Owls
10-3N/AN/A8-12-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 15th@WKUW 25-6+10 WU 55.5FIU +310
Oct 4th@UCONNL 10-51+7 LO 52.5UCONN +220
Sep 20thDELL 16-38-4.5 LU 55DEL -188
Sep 13thFAUW 38-28-2.5 WO 56.5FIU -130
Sep 6th@PSUL 0-34+42 WU 53.5-

Panthers vs. Owls Injury Updates

Panthers Injuries

  • Jake Helfrich
    QB

    Helfrich is out for season with chest

    Out for Season

Owls Injuries

    Team Stats
    498
    Total Yards
    503
    58
    Total Plays
    74
    8.586206896551724
    Yards Per Play
    6.797297297297297
    284
    YDS
    296
    12/17
    Comps/Atts
    22/37
    16.705882352941178
    YPA
    8
    2/0
    TDs/INTs
    1/0
    0/0
    Sacks/Yards
    2/11
    214
    Rush Yards
    207
    41
    Attempts
    37
    5.219512195121951
    YPC
    5.594594594594595
    4
    TDs
    2

    Turnovers

    0
    Fumbles Lost
    0
    0
    Interceptions
    0

    Efficiency

    4/4 100%
    Redzone
    4/5 80%
    3/9 0%
    3rd Down
    6/15 0%
    1/1 0%
    4th Down
    0/2 0%

    First Downs

    20
    Total
    23
    7
    Pass
    15
    12
    Rush
    7
    1
    Penalty
    1
    7/56
    Penalties/Yards
    9/65

    Owls vs. Panthers Odds Comparison

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    Owls at Panthers Team Totals

    MatchupOverUnder
    Owls
    10-4
    o26-114
    u26-112
    Panthers
    7-6
    o23-116
    u23-112