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Clemson vs. Wake Forest Odds, Pick, Betting Prediction: Expect Growing Pains for Each Offense (Sept. 12)

Clemson vs. Wake Forest Odds, Pick, Betting Prediction: Expect Growing Pains for Each Offense (Sept. 12) article feature image

Streeter Lecka/Getty Images. Pictured: Nasir Greer (3) and Trevor Lawrence (16).

  • Clemson is a monster favorite over Wake Forest in their season openers on Saturday.
  • Collin Wilson is expecting a ramp-up period for a Tigers' offense that's breaking in a new offensive line. He also expects Wake to have serious growing pains after replacing so many pieces on offense.
  • Get his full breakdown and Clemson vs. Wake Forest pick below.

Clemson vs. Wake Forest Odds

Wake Forest Odds +33.5 [BET NOW]
Clemson Odds -33.5 [BET NOW]
Over/Under 54.5 [BET NOW]
Time 7:30 p.m. ET

Odds as of Friday at 1:00 a.m. ET and via PointsBet, where you can get $250 FREE instantly after signing up AND your bets automatically sync to the Action app. Learn more about BetSync here.

This series has been flat-out ugly over the past two years, as Clemson has outscored Wake Forest 115-6 over the past eight quarters of play.

Following Wake Forest’s 63-6 loss in 2018, head coach Dave Clawson stated that Clemson ran base plays with its second-string offense and still ran up the score.

Saturday’s game has a chance to turn out similarly.

Check out our free NCAAF odds page, which automatically surfaces the best line for every game.

Wake Forest Demon Deacons

The Demon Deacons program is managing players that have tested positive for COVID-19, and contact tracing procedures will keep unknown players out of this game.

While Clemson can plug and play a fresh class of blue-chip recruits, Wake Forest will be looking for answers on an offense that returns only 32% of its 2019 production. The Demon Deacons’ biggest names are no longer with the team, including quarterback Jamie Newman and  wide receivers Sage Surratt, Kendall Hinton and Scotty Washington.

The Deacs will be searching for an offensive identity against Brett Venables’ defense, which consistently ranks among the nation’s top units in success rate and havoc.

Clemson Tigers

However, Clemson will be looking for offensive answers of its own. Heisman hopeful Trevor Lawrence will have four fresh offensive linemen protecting him this season. The Tigers’ offensive line features future NFL Draft first-rounder Jackson Carman, but there are 18 other Clemson offensive linemen with zero career starts and little playing experience.

That lack of familiarity and continuity may also affect the passing game, as Lawrence will be without his top two receivers in Tee Higgins and Justyn Ross. Wide receiver Frank Ladson Jr. reports the most third-down targets among Clemson’s returning wide receiving corps, but he only logged eight all season in 2019.

Betting Analysis & Pick

The easy wager is to look at the cumulative score from the past two seasons and assume that Clemson will roll. That may happen, but only after Lawrence establishes a strong rapport with his new offensive linemen and inexperienced receiving targets.

Clemson’s offensive learning curve may not be especially steep, but it should be enough for a talented Wake Forest front-seven to get some pressure early and keep the Lamborghini in third gear through the first half.

The Bet: First Half Under 33

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