The Colorado State Rams take on the Wyoming Cowboys in Laramie, Wyo. Kickoff is set for 7:30 p.m. EDT on CBS Sports Network.
Wyoming is favored by 4.5 points on the spread with a moneyline of -200. The total is set at 47.5 points.
Here’s my Colorado State vs. Wyoming prediction and college football picks for Saturday, October 25, 2025.
Colorado State vs Wyoming Prediction
- Colorado State vs. Wyoming Pick: Colorado State +4.5 (-110, bet365)
My Wyoming vs. Colorado State best bet is on the Rams to cover. Find the best line available on our live NCAAF odds page.
Colorado State vs Wyoming Odds
| Colorado State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+4.5 -110 | 47.5 -110o / -110u | +165 |
| Wyoming Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-4.5 -110 | 47.5 -110o / -110u | -200 |
- Colorado State vs Wyoming point spread: Wyoming -4.5 (-110), Colorado State +4.5 (-110)
- Colorado State vs Wyoming over/under: 47.5 (-110o / -110u)
- Colorado State vs Wyoming moneyline: Colorado State +165, Wyoming -200
Colorado State vs Wyoming Preview
This game triggered one of our Action PRO betting systems, powered by Evan Abrams.
Early Road Redemption is a college football system that identifies value on visiting teams in the opening stretch of the season after they have underperformed against the spread in their previous outing.
The market often punishes these teams too harshly for a single early loss, leading to inflated lines in the next matchup.
By narrowing the spread range between modest underdogs and double-digit spots, the system captures situations where the road team is competitive but overlooked.
These games are played in manageable weather conditions and typically produce lower-scoring totals, which reduces volatility and keeps contests closer than expected.
When teams in their first eight games seek redemption on the road after a poor showing against the spread, they frequently outperform expectations, making this a profitable angle.
Pick: Colorado State +4.5 (-110, bet365)
