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Cardinals vs. Saints Odds & Betting Predictions - September 7, 2025

Cardinals at Saints

5:00 pm • CBS

Arizona Cardinals

2-4
20
20 - 13

New Orleans Saints

2-4
13

Cardinals at Saints Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
2-4
-5.5-108
o44.5-105
-260
Saints
2-4
+5.5-111
u44.5-115
+205
location pinSunday 5:00 p.m.
September 07, 2025
Caesars SuperdomeNew Orleans
Cardinals vs. Saints Expert Picks
Matt Moore
Matt Moore
Last 30d: 37-41-8 (-0.9u)
NO +6.5-110
1.1u
They have no quarterback. Their roster is terrible. Kellen Moore maybe terrible. But I cannot justify the idea of the Cardinals being eight or more favorites against anyone in week one if we flip home field
Tyler Shoemaker
Tyler Shoemaker
Last 30d: 33-39-0 (-1.7u)
NO +7.5-120
5u
Under 42.5-110
5u
Matthew Freedman
Matthew Freedman
Last 30d: 0-0-0 (+0.0u)
Under 44.5-112
1u
Projection: 42.8. For more, check out the Fantasy Life game model.
Doug Ziefel
Doug Ziefel
Last 30d: 370-388-7 (+21.5u)
ARI -4.5-105
0.5u
K.Murray u1.5 Pass TDs-122
0.61u
R.Shaheed o32.5 Rec Yds-120
0.5u
T.McBride o61.5 Rec Yds-110
0.55u
J.Johnson u2.5 Recs+115
0.43u
J.Conner u16.5 Rush Att-110
0.5u
Jeremiah Rose
Jeremiah Rose
Last 30d: 44-54-2 (-2.6u)
J.Conner Anytime TD Scorer Yes (Live)-110
0.18u
Boyd / FanDuel
Ryan Minion
Ryan Minion
Last 30d: 222-221-2 (+4.1u)
ARI -5.5-130
$1.00
OldSchool0909
Last 30d: 40-47-1 (-3.0u)
NO +6-110
1u
Collin Whitchurch
Collin Whitchurch
Last 30d: 98-124-3 (+1.0u)
G.Dortch Anytime TD Scorer Yes+825
0.25u
Kyle Murray
Kyle Murray
Last 30d: 152-130-9 (+26.8u)
ARI -5.5-120
1u
Brian Bitler
Brian Bitler
Last 30d: 65-80-4 (-39.8u)
Over 43-110
3u
NO +6.5-110
3u
Chris Gimino
Chris Gimino
Last 30d: 6-7-0 (-0.6u)
T.Benson o22.5 Rush Yds-115
0.87u
Brandon Kravitz
Brandon Kravitz
Last 30d: 53-54-1 (+8.8u)
ARI -4-115
0.87u
NO +6.5-105
0.8u
RoyalsProps
RoyalsProps
Last 30d: 32-39-2 (-12.4u)
K.Murray o23.5 Rush Yds-120
1u
MGM
ARI -5.5-117
1u
PX
Gilles Gallant
Gilles Gallant
Last 30d: 22-63-1 (-5.3u)
R.Shaheed Anytime TD Scorer Yes+350
0.6u
NEED FOR SHAHEED!!!
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 0-0-0 (+0.0u)
Over 44.5-105
0.5u
Topper
Topper
Last 30d: 175-150-8 (+18.1u)
Over 42.5-115
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 86-98-1 (+18.6u)
ARI -6.5-105
1u
The Propfessor
The Propfessor
Last 30d: 0-0-0 (+0.0u)
J.Johnson o25.5 Rec Yds-105
0.71u
Babs .
Babs .
Last 30d: 43-35-1 (+1.3u)
C.Olave o45.5 Rec Yds-105
0.95u
M.Harrison o4.5 Recs-105
0.95u

Cardinals vs. Saints Previews & Analysis

  • 2 Huge TD Edges for Broncos-Titans (4:05 pm ET) article feature image

    2 Huge TD Edges for Broncos-Titans (4:05 pm ET)

    Alex Kolodziej•
    Sep 7, 2025 UTC
  • Cardinals vs. Saints Parlay: +195 SGP for NFL Week 1 article feature image

    Cardinals vs. Saints Parlay: +195 SGP for NFL Week 1

    Dead President Picks•
    Sep 7, 2025 UTC
  • Gallant's TD Picks & Preview for Every NFL Game article feature image

    Gallant's TD Picks & Preview for Every NFL Game

    Gilles Gallant•
    Sep 7, 2025 UTC
  • NFL Best Bets: Our Favorite Spread & Over/Under Picks article feature image

    NFL Best Bets: Our Favorite Spread & Over/Under Picks

    Action Network Staff•
    Sep 7, 2025 UTC
See more NFL Coverage Right Arrow

Cardinals vs. Saints Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Cardinals vs. Saints Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Saints

37%

Bets%

63%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Saints are 1-4 in their last 5 games.
  • Saints are 2-3 in their last 5 games against the spread
  • Saints are 3-0 in their road games against the spread
  • The totals have gone OVER in 4 of Saints' last 5 games
  • The totals have gone OVER in 2 of Saints' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Saints		3-30-33-00-22-1
Cardinals		3-30-23-10-13-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Saints		4-22-12-12-01-2
Cardinals		3-31-12-21-02-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Saints		2-4N/AN/A0-21-2
Cardinals		2-4N/AN/A0-12-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 23rdDENL 19-28+2.5 LO 38.5DEN +120
Aug 17thJACW 17-17+2.5 WU 40.5JAC +112
Aug 10th@LACL 13-27+2.5 LO 39LAC +120
Jan 5th@TBL 19-27+14.5 WO 44.5TB +722
Dec 29thLVL 10-25+2 LU 37.5LV +105

Saints vs. Cardinals Injury Updates

Saints Injuries

  • Travis Etienne
    RB

    Etienne is out with hamstring

    Out

  • Jordyn Tyson
    WR

    Tyson is out with hamstring

    Out

Cardinals Injuries

  • James Conner
    RB

    Conner is out with foot

    Out

  • Hunter Long
    TE

    Long is out with knee

    Out

  • Jeremiyah Love
    RB

    Love is doubtful with ankle

    Doubtful

See more NFL Injuries Right Arrow
Team Stats

Total

276
Total Yards
315
61
Total Plays
69
4.5
Yards Per Play
4.6

Passing

163
YDS
214
21/29
Comps/Atts
27/46
3.824
YPA
4.426
2/0
TDs/INTs
0/0
5/33
Sacks/Yards
1/6

Rushing

146
Rush Yards
107
27
Attempts
22
5.407
YPC
4.864
0
TDs
1

Turnovers

0
Fumbles Lost
0
0
Interceptions
0

Efficiency

2/3 66.67%
Redzone
1/4 25%
6/13 0%
3rd Down
5/14 0%
0/0 0%
4th Down
1/2 0%

First Downs

19
Total
21
11
Pass
12
5
Rush
5
3
Penalty
4

Misc

9/54
Penalties/Yards
13/89
33:46
Possession
26:14

Cardinals vs. Saints Odds Comparison

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Cardinals at Saints Team Totals

MatchupOverUnder
Cardinals
2-4
N/A
N/A
Saints
2-4
N/A
N/A