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49ers vs. Rams Odds & Betting Predictions - October 3, 2025

49ers at Rams

12:15 am • Amazon Prime Video

San Francisco 49ers

3-0
@

Los Angeles Rams

2-1

49ers at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
3-0
+1.5
+3-110
o46.5-115
+130
Rams
2-1
u47.5
-3-110
u46.5-105
-154
location pinFriday 12:15 a.m.
October 03, 2025
SoFi StadiumInglewood
thermometer image75°Fahrenheit
rain image0%Rain
wind image7Wind

49ers vs. Rams Props

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Line Movement Tracker

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49ers vs. Rams Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Rams

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Rams are 2-1 in their last 5 games.
  • Rams are 2-1 in their last 5 games against the spread
  • Rams are 1-1 in their road games against the spread
  • The totals have gone OVER in 2 of Rams' last 3 games
  • The totals have gone OVER in 0 of Rams' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams		2-11-01-12-00-1
49ers		2-10-12-02-1N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams		2-10-12-01-11-0
49ers		1-20-11-11-2N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams		2-1N/AN/A2-00-1
49ers		3-0N/AN/A3-0N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 21st@PHIL 26-33+3.5 LO 45.5PHI +170
Sep 14th@TENW 33-19-5.5 WO 41.5LA -250
Sep 7thHOUW 14-9-3 WU 43LA -168
Aug 23rd@CLEL 17-19+10 WU 37CLE +360
Aug 16thLACW 23-22+8 WO 39.5LA +297

Rams vs. 49ers Injury Updates

Rams Injuries

    49ers Injuries

    • George Kittle
      TE

      Kittle is out with hamstring

      Out

    • Brandon Aiyuk
      WR

      Aiyuk is out with knee

      Out

    • Jacob Cowing
      WR

      Cowing is out with hamstring

      Out

    • Jordan Watkins
      WR

      Watkins is doubtful with ankle

      Doubtful

    • Jordan James
      RB

      James is doubtful with finger

      Doubtful

    See more NFL Injuries Right Arrow
    Player Stats
    • passing yards
      Matthew Stafford logo
      Matthew Stafford
      739
      pyds
    • passing touchdowns
      Matthew Stafford logo
      Matthew Stafford
      5
      ptd
    • rushing yards
      Kyren Williams logo
      Kyren Williams
      226
      ryds
    • rushing touchdowns
      Puka Nacua logo
      Puka Nacua
      1
      rtd
    Depth Charts
    Right Arrow
    Starter2ND3RD4TH
    QBMatthew StaffordJimmy GaroppoloStetson Bennett
    RBKyren WilliamsBlake CorumJarquez HunterRonnie Rivers
    WRTutu AtwellXavier Smith
    TETyler HigbeeColby ParkinsonTerrance FergusonDavis AllenMark Redman
    LTAlaric JacksonD.J. HumphriesAJ Arcuri
    LGSteve AvilaWyatt Bowles
    CColeman SheltonBeaux LimmerDylan McMahon
    RGKevin DotsonJustin Dedich
    RTRob HavensteinWarren McClendonDavid Quessenberry
    RDEBraden FiskeLarrell MurchisonDesjuan Johnson
    LCBDarious WilliamsEmmanuel ForbesA.J. GreenCam Lampkin
    SSKam CurlJaylen McCollough
    FSKamren KinchensTanner IngleNate Valcarcel
    RCBAhkello WitherspoonCobie Durant
    PEthan Evans
    HEthan Evans
    PRXavier Smith
    KRJordan WhittingtonBlake Corum
    LSAlex Ward
    NBQuentin LakeJosh Wallace
    DTKobie TurnerTyler DavisJack Heflin
    RILBOmar SpeightsElias Neal
    LWRDavante AdamsJordan WhittingtonTru Edwards
    RWRPuka NacuaKonata MumpfieldBrennan Presley
    NTPoona FordTy HamiltonBill Norton
    LILBNate LandmanTroy ReederShaun Dolac
    LOLBByron YoungJamil Muhammad
    ROLBJared VerseJosaiah StewartNick Hampton
    KJoshua Karty
    Team Stats

    Passing

    814
    YDS
    710
    79/115
    Comps/Atts
    63/96
    7.304
    YPA
    7.698
    6/3
    TDs/INTs
    5/2
    5/26
    Sacks/Yards
    5/29

    Rushing

    269
    Rush Yards
    381
    82
    Attempts
    81
    3.28
    YPC
    4.704
    0
    TDs
    3

    Turnovers

    Fumbles Lost
    3
    Interceptions
    2

    Efficiency

    5/11 45.46%
    Redzone
    6/13 46.15%
    17/39 0%
    3rd Down
    15/35 0%
    3/4 0%
    4th Down
    2/3 0%

    First Downs

    66
    Total
    62
    44
    Pass
    35
    16
    Rush
    22
    6
    Penalty
    5

    Misc

    /
    Penalties/Yards
    /
    Possession

    49ers vs. Rams Odds Comparison

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    49ers at Rams Team Totals

    MatchupOverUnder
    49ers
    3-0
    N/A
    N/A
    Rams
    2-1
    N/A
    N/A