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The Arizona Cardinals (1-4) and Los Angeles Rams (2-3) square off today in NFL Week 6. Kickoff is set for 4:05 p.m. ET from SoFi Stadium in Inglewood, Calif. The game will broadcast live on FOX.
The Rams are 12.5-point favorites over the Cardinals on the spread, with the over/under set at 51.5 total points. Los Angeles is a -770 moneyline favorite to win outright, while Arizona is a +540 underdog to pull off the upset.
Let's get into my Cardinals vs Rams predictions for today's Week 6 game.
Cardinals vs Rams Prediction
- Cardinals vs Rams pick: Rams -12.5 (-108)
My Cardinals vs. Rams best bet is Los Angeles to cover the spread (-12.5), with the best price currently available at FanDuel. Make sure to find the best odds by checking our live NFL odds page.
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Cardinals vs Rams Odds
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+12.5 -112 | 51.5 -115o / -105u | +540 |
| Rams Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-12.5 -108 | 51.5 -115o / -105u | -770 |
- Cardinals vs Rams spread: Cardinals +12.5, Rams -12.5
- Cardinals vs Rams total: over/under 51.5
- Cardinals vs Rams moneyline: Cardinals +540, Rams -770
Cardinals vs Rams NFL Week 6 Preview
Arizona Cardinals Betting Preview: Reality Hurts
The Cardinals immediately forced us to reevaluate them after an opening-week win over the Chargers, but reality has set in — Arizona is a pretty bad team that just managed to look good against an even worse team.
The Cardinals' offensive line injuries have caught on to them, and Jacoby Brissett is simply not the same quarterback when forced to operate under pressure. Prized draft pick Jeremiyah Love has also large been ineffective while also nursing a lingering ankle injury.
When stepping up in class against the Seahawks and Lions, Arizona was blown out by 24 points in both contests — and both of those games were at home.
The Cardinals defense simply cannot generate stops, and the team may already be sellers at this juncture of the season, having just parted ways with Marvin Harrison Jr. last week.
Los Angeles Rams Betting Preview: The Perfect Get-Right Spot
The Rams have navigated a ridiculously difficult travel schedule and are finally in a prime get-right spot.
Sean McVay absolutely owns the Cardinals. He is 16-3 straight up and 14-4-1 against the spread against Arizona — the best mark against any opponent by any head coach in the Super Bowl era.
Los Angeles can consistently generate defensive pressure against Jacoby Brissett without needing to blitz, and the offense should be able to march up and down the field against a lackluster Arizona defensive unit.
We rightfully bashed McVay's game management from Monday Night Football, but the talent mismatch here is huge.
Cardinals vs Rams Prediction, Betting Analysis
You generally want to avoid laying double digits in the NFL, but this matchup has blowout written all over it.
Sean McVay historically dominates the Cardinals, and Arizona's battered offensive line seems destined to collapse against the Rams' defensive front.
Expect a big bounce-back performance from Los Angeles.
Pick: Rams -12.5 (-108)
