NFL Odds & Pick for Buffalo Bills vs. San Francisco 49ers: Monday Night Football’s Spread Betting Edge

NFL Odds & Pick for Buffalo Bills vs. San Francisco 49ers: Monday Night Football’s Spread Betting Edge article feature image
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Photo by Bryan Bennett/Getty Images. Pictured: Dawson Knox #88 and Josh Allen #17 of the Buffalo Bills celebrate

  • In the second game of tonight's NFL doubleheader, the Buffalo Bills take on the San Francisco 49ers on Monday Night Football.
  • According to updated NFL odds, the 49ers are short home favorites against the Bills.
  • Using our NFL PRO Projections, we detail the big spread betting edge for Bills vs. 49ers.

NFL Odds: Bills vs. 49ers

Bills Odds +1
49ers Odds -1
Over/Under 47.5
PRO Projections Bills -1.4 | O/U: 47.4
Time/Channel  8:15 p.m. ET, ESPN
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Not only is Bills vs. 49ers game offering the biggest betting edge of tonight’s NFL doubleheader, but it’s also one of the top edges from NFL Week 13 overall.

By combining projected spreads and over/unders from our NFL model and comparing to the latest odds, we can quickly determine which lines are offering the smartest betting opportunities across an entire slate of games.

Using our NFL PRO Projections, let’s look at the Bills vs. 49ers wager that’s popping with value on Monday night.

NFL Picks: Bills vs. 49ers

The betting market sees tonight’s Bills vs. 49ers game as essentially a toss up, evidenced by the 1-point spread (click here for live NFL odds).

But while San Francisco is listed at -1 across the market, our PRO Projections make Buffalo a 1.4-point road favorite in this game.

The difference between getting a the Bills at +1 and our projection of -1.4 translates into a +3.8% edge with the Buffalo spread, earning a B- grade.

Want our top betting model edges for every NFL game? Test drive a FREE trial of our Action PRO subscription right now.

PRO Projections Pick: Bills +1

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