Our football staff is focused on six of Sunday's biggest games for our NFL predictions in Week 12 on November 23.
First, we'll target Colts vs Chiefs and Steelers vs Bears in the early window. Later in the afternoon, we have a pair of picks for Cowboys vs Eagles and Falcons vs Saints. We also have picks for Vikings vs Packers, Browns vs Raiders and more.
Let's dive into our expert NFL picks and best bets for the Week 12 Sunday slate.
NFL Predictions & Picks — Week 12
| Game | Time (ET) | Pick |
|---|---|---|
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 1:00 p.m. | |
  | 4:05 p.m. | |
  | 4:25 p.m. | |
  | 4:25 p.m. | |
Specific betting recommendations come from the sportsbook offering preferred odds as of writing. Always shop for the best price using our NFL Odds page, which automatically surfaces the best lines for every game. | ||
Colts vs Chiefs
The Colts enter this matchup allowing 20.6 points per game while the Chiefs are averaging 25.4 points per game offensively.
The Colts have been effective running the ball, gaining 145.3 rushing yards per game, which could help control the clock against the Chiefs' passing attack.
The Colts defense has generated nearly three sacks per game and 14 turnovers on the season, creating potential for momentum shifts.
Time of possession and rushing efficiency could be key factors in keeping the game close.
Pick: Colts +3.5 (-115)
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Vikings vs Packers
By Bet Labs
The NFL system titled "Great Condition Divisional Road 'Dogs" works on the belief that divisional underdogs traveling in good weather during the early and middle parts of the season carry hidden value.
In the NFL, division games are often tighter and more unpredictable because of the familiarity and rivalry factor which narrows the talent gap.
When the visiting team is the 'dog in November, conditions are generally stable with limited wind allowing both teams to execute their normal game plans without weather being a major factor.
In these spots the public often overvalues the home side, yet divisional familiarity and the motivational boost of playing a rival make the road 'dog more competitive than the line suggests.
In addition, our Chris Raybon is on the Vikings moneyline for this game.
Pick: Vikings +6.5 (-110)
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Steelers vs Bears
By Dylan Wilkerson
The under in this game looks like a strong play.
Pittsburgh has run fewer than 60 offensive snaps per game — the lowest in the NFL — which limits scoring chances and keeps its game totals low.
The Steelers have scored heavily off of turnovers and short fields this season, while the Bears lead the league in turnover differential (+16).
Both teams rank among the luckiest, according to Action Network's Luck Rankings, meaning they’ve scored more points than their play suggests is sustainable.
With two decent defenses, points will be hard to come by. This game stays under 45.5.
Pick: Under 45.5 (-110)
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Browns vs Raiders
By Bet Labs
The NFL system titled "Road 'Dog, Low Total After Bad Season" focuses on how struggling teams from the previous year can quietly outperform expectations when catching points on the road in lower scoring games.
Teams with six or fewer wins from the prior season are often undervalued, but when they are priced as moderate underdogs in contests with totals capped at 50, the environment favors closer outcomes and makes points more valuable.
Playing on Sundays later in the year amplifies this effect, as late-season contests often bring unique motivations and divisional familiarity.
In these situations, public bias against bad teams collides with the natural tendency for low total games to stay tight, creating profitable opportunities for road underdogs to cover.
Pick: Browns +3.5 (-110)
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Eagles vs Cowboys
By Dylan Wilkerson
The Cowboys +3.5 against the Eagles offers strong value.
The Eagles top Action Network's luck rankings as the NFL's luckiest team, overperforming expected outcomes, while the Cowboys rank a solid 17th — positioning them for positive regression in a divisional clash.
The Cowboys boast the league's sixth-ranked third-down conversion rate (42.7%), which should help them sustain drives and control the clock against Philly's opportunistic but regression-prone defense.
Offensively, the Cowboys operate at a blistering pace, with 70 snaps per game and a 4.26% big-time throw rate, which fuels explosive plays that keep scores tight.
I think Dallas wins this NFC East matchup.
Pick: Cowboys +3.5 (-120)
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Falcons vs Saints
By Dylan Wilkerson
Action Network's Luck Rankings have these teams as two of the unluckiest in football.
They have been scoring fewer points than expected, and I think some regression is inbound.
Although Michael Penix Jr. is out, Kirk Cousins is not the worst backup quarterback if you are looking for points, and Tyler Shough hasn't been awful in his limited playing time.
Both of these teams have allowed a 60% touchdown conversion rate in the red zone.
With the total so low, I think this game could sail over the number.
Pick: Over 40.5 (-110)
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