The Minnesota Twins host the Chicago Cubs on Tuesday, July 8, 2025. First pitch from Target Field is scheduled for 7:40 p.m. ET; the game will be broadcast on Marquee and MLB.TV.
The Cubs enter as -131 favorites on the moneyline, while the Twins come in at +110 to pull off the upset. The over/under, meanwhile, sits at 9 total runs.
Find my Cubs vs Twins prediction and MLB betting preview below, as well as probable pitchers, betting trends, injury reports and more.
Cubs vs Twins Prediction
- Cubs vs. Twins Pick: Cubs ML -135
My Twins vs. Cubs best bet is on Chicago to win this game. Make sure to find the best odds by checking our live MLB odds page.
Cubs vs Twins Odds
| Cubs Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
-1.5 +125 | 9 -115o / -105u | -131 |
| Twins Odds | ||
|---|---|---|
| Run Line | Total | Moneyline |
+1.5 -152 | 9 -115o / -105u | +110 |
Cubs vs Twins Projected Starting Pitchers
Cubs vs Twins MLB Betting Preview
Tuesday's Cubs vs. Twins matchup fits a historically profitable betting system in our Bet Labs database.
Titled "Road Flip Bet," this system targets regular-season MLB matchups where a team shifts from playing at home to playing on the road in a non-division game and becomes a slight road favorite.
It looks for teams that were at home in their last game but now travel while still holding market respect, indicated by a short favorite price between -120 and -140.
By focusing on non-division matchups, the system removes familiarity edges and isolates travel spots where the market's confidence in the team's quality outweighs any concerns about the venue change.
These situations often highlight teams in rhythm, carrying momentum from a homestand into a new series while catching the opponent off guard without the added tension of a division rivalry.
By backing these mild road favorites during the regular season, the system leverages travel transitions where team quality and market pricing align, capitalizing on the confidence that the team can handle the shift in environment without a drop in performance.
Cubs vs Twins Pick, Betting Analysis
The Cubs have won six of their last eight games and are 7-3 in their last 10, while the Twins have lost two of their last three series and come in with a 5-5 record in their last 10 games.
Given Chicago's hot streak and the fact that it enters as a favorite tonight — a big indicator in the market — we'll target the Cubs on the moneyline at -140 or better.
Pick: Cubs ML -135 (Play to -140)
Moneyline
Our best bet for this game is to take the Cubs on the moneyline. They've been on a hot streak of late and enter this matchup as the favorites, indicating confidence from the market.
Run Line (Spread)
While we're backing the Cubs on the moneyline, we're staying away from the run line in this interleague clash.
Over/Under
We don't have a bet on the total in this game.
