The St. Louis Cardinals host the Chicago White Sox on September 11, 2026. First pitch from Busch Stadium is scheduled for 8:15 p.m. EDT. The game will be broadcast on CHSN.
The White Sox are favored by -112 on the moneyline and by -1.5 on the run line. The Cardinals are -104 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and White Sox vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
White Sox vs Cardinals Prediction
- White Sox vs Cardinals Pick: Matthew Liberatore Over 5.5 K (+102)
My White Sox vs Cardinals best bet is on Matthew Liberatore to record over 5.5 strikeouts. Make sure to find the best odds by checking our live MLB odds page and be sure to download the Action Network app for more picks and analysis.
<
div>
White Sox vs Cardinals Odds
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +146 | 8.5 -100o / -122u | -112 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -178 | 8.5 -100o / -122u | -104 |
- White Sox vs Cardinals moneyline: White Sox -112, Cardinals -104
- White Sox vs Cardinals over/under: 8.5 (-100o / -122u)
- White Sox vs Cardinals spread: White Sox -1.5 (+146), Cardinals +1.5 (-178)
White Sox vs Cardinals Probable Pitchers
| Anthony Kay (LHP, CHW) | Stat | Matthew Liberatore (LHP, STL) |
|---|---|---|
| 9-8 | W-L | 5-14 |
| 1.0 | fWAR (FanGraphs) | 1.1 |
| 4.47/4.97 | ERA / xERA | 5.57/4.88 |
| 4.85/4.63 | FIP / xFIP | 4.53/3.98 |
| 10.4% | K-BB% | 15.6% |
| 44.7% | GB% | 36.5% |
| .288 | BABIP | .338 |
| 104 | Stuff+ | 98 |
| 104 | Location+ | 100 |
White Sox vs Cardinals MLB Betting Preview, Expert Pick
Matthew Liberatore has a career-high 23.7% strikeout rate this season, but he has a 28.2% rate since June 30! Liberatore is producing strikeouts and limiting walks at an excellent rate in this span. However, he continues to struggle due to hard contact.
Nevertheless, the Chicago White Sox offer a solid spot to bet on Liberatore's strikeout line. His line is set at 5.5, but he has crossed this mark in 8 of his past 12 starts. Liberatore has pitched at least five innings in 9 of these 12 starts and could continue his trends of bulky outings and strikeouts.
The White Sox have the fifth-highest strikeout rate in baseball (24.8%). They have the sixth-highest rate in the past two weeks (25.1%) and are performing as a below-average offense (87 wRC+).
Liberatore has a lower strikeout rate at home (20.1%) than on the road (27.5%), yet he has produced 16 total Ks in his past two home starts combined. Today's line should be reasonable to cross early in his start.
Pick: Matthew Liberatore Over 5.5 K (+102)
