The St. Louis Cardinals host the Cincinnati Reds on September 15, 2025. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT; the game will be broadcast on FDSMW.
Find my MLB betting preview and Reds vs Cardinals prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Reds vs Cardinals Prediction
- Reds vs Cardinals pick: Under 8.5
My Reds vs Cardinals best bet is on the under total runs. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cardinals Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -205 | 8.5 -110o / -110u | +105 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +165 | 8.5 -110o / -110u | -125 |
Reds vs Cardinals Projected Starting Pitchers
| RHP Zack Littell (CIN) | Stat | LHP Matthew Liberatore (STL) |
|---|---|---|
| 9-8 | W-L | 7-12 |
| 1.3 | fWAR (FanGraphs) | 1.5 |
| 3.78/4.64 | ERA /xERA | 4.35/4.77 |
| 4.94/4.35 | FIP / xFIP | 4.14/4.41 |
| 1.12 | WHIP | 1.33 |
| 13.0% | K-BB% | 11.9% |
| 39.9% | GB% | 38.3% |
| 86 | Stuff+ | 96 |
| 104 | Location+ | 99 |
Reds vs Cardinals Prediction, Betting Analysis
The Cincinnati Reds (74–75) and St. Louis Cardinals (73–77) open their three-game set tonight with both teams long removed from the NL Central race. St. Louis is priced as a slight -125 favorite on the moneyline, while Cincinnati comes back at +105. Oddsmakers have set the total at 8.5 runs.
The pitching matchup features Zack Littell for the Reds against Matthew Liberatore for the Cardinals. Neither arm has been dominant this season, but the bigger factor in this handicap is external: the conditions.
Evan Abrams’ “Wind Blowing In, Short and Long Term” system highlights specific stadiums where wind direction plays an outsized role in scoring. Busch Stadium in St. Louis has consistently shown suppressed run production when the wind blows in, cutting down on carry to the gaps and power alleys. Historically, this setup has favored Under bettors both in the short sample and over multiple seasons.
With both offenses sputtering down the stretch and neither team fighting for a playoff berth, motivation is questionable, and the suppressed run environment becomes even more appealing. Even if Littell and Liberatore allow traffic, the reduced power potential makes crooked innings less likely.
Pick: Under 8.5 (-110, bet365)
Reds vs Cardinals Betting Trends
