The St. Louis Cardinals host the Cincinnati Reds on June 5, 2026. First pitch from Busch Stadium is scheduled for 8:15 p.m. ET. The game will be broadcast on CINR.
The Cardinals are favored by -145 on the moneyline and by -1.5 on the run line. The Reds are +120 on the moneyline and +1.5 on the run line. The total is set at 9 runs.
Find our MLB picks and Reds vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Reds vs Cardinals Prediction
- Reds vs Cardinals Pick: Over 9 (-105)
Our Reds vs Cardinals best bet is Over 9 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cardinals Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -170 | 9 -105o / -115u | +120 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +140 | 9 -105o / -115u | -145 |
- Reds vs Cardinals moneyline: Reds +120, Cardinals -145
- Reds vs Cardinals over/under: 9 (-105o / -115u)
- Reds vs Cardinals spread: Reds +1.5 (-170), Cardinals -1.5 (+140)
Reds vs Cardinals Probable Pitchers
| RHP Brady Singer (CIN) | Stat | RHP Kyle Leahy (SL) |
|---|---|---|
| 2-5 | W-L | 5-3 |
| -0.6 | fWAR (FanGraphs) | 0.1 |
| 6.18 / 6.51 | ERA / xERA | 4.25 / 6.27 |
| 6.89 / 4.71 | FIP / xFIP | 4.74 / 4.20 |
| 8.4 | K-BB% | 9.6 |
| 39.6 | GB% | 45.5 |
| .323 | BABIP | .329 |
| 91 | Stuff+ | 89 |
| 96 | Location+ | 105 |
Reds vs Cardinals MLB Betting Preview
Our own Sean Zerillo projects an edge on the total for this matchup.
While the consensus line sits at 9, Zerillo projects around 9.63 runs for this game, representing a 4% edge against the market, making the over the best choice with a B- grade on our system.
Also, the number of bets and percentage of money show increasing support for this option heading into tonight's first pitch.
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
Reds vs Cardinals Pick, Betting Analysis
Both starters tonight have concerning metrics. Their expected ERAs are over 6.00, with Brady Singer at 6.51 and Kyle Leahy at 6.27, and their WHIPs are also quite high: Singer with 1.69 and Leahy with 1.56.
The Reds have been the 10th-best offense in the league in wRC+ for the past 30 days with 102, and the Cardinals rank 14th at home in wRC+ with the same rating.
Cincinnati also has one of the worst bullpens in MLB, ranking 27th with a 4.97 ERA. St. Louis, at 17th and 4.28, isn't reassuring either.
Pick: Over 9 (-105, BetMGM)
