The St. Louis Cardinals host the Cincinnati Reds on June 22, 2025. First pitch from Busch Stadium is scheduled for 2:15 p.m. EDT; the game will be broadcast on FDSOH.
The Cardinals are looking to finish the home sweep after taking the first two games, but will face a tough matchup against the Reds' Andrew Abbott. Miles Mikolas will get the ball for St. Louis.
Find my MLB betting preview and Reds vs Cardinals prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Reds vs Cardinals Prediction
- Reds vs Cardinals picks: Under 9.5 (-118, BetMGM)
My Reds vs Cardinals best bet is Under 9.5. Make sure to find the best odds by checking our live MLB odds page.
Reds vs Cardinals Odds
| Reds Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +140 | 9.5 -102o / -118u | -115 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -170 | 9.5 -102o / -118u | -105 |
Reds vs Cardinals Projected Starting Pitchers
| LHP Andrew Abbott (CIN) | Stat | RHP Miles Mikolas (STL) |
|---|---|---|
| 6-1 | W-L | 4-4 |
| 1.6 | fWAR (FanGraphs) | 1.2 |
| 1.84 / 2.94 | ERA / xERA | 4.35 / 4.36 |
| 3.49 / 3.94 | FIP / xFIP | 3.73 / 4.72 |
| 1.01 | WHIP | 1.30 |
| 18.1 | K-BB% | 8.8 |
| 31.1 | GB% | 39.8 |
| 96 | Stuff+ | 89 |
| 100 | Location+ | 107 |
Reds vs Cardinals Preview
The Reds starter, Andrew Abbott, already faced the Cardinals this season and did a pretty good job.
The left-hander only allowed an unearned run and three hits in four complete innings in an outing that was shortened because of an hour-and-a-half rain delay that prompted both managers to use their bullpen when play resumed.
At 26 years old, Abbott is enjoying a career season with a 1.84 ERA, 1.01 WHIP, .196 average against, and six wins already, only four shy of his best total.
In addition, St. Louis has issues when facing southpaws: the Cardinals' 96 wRC+ for the season drops to a paltry 75 wRC+ against left-handed pitching.
Miles Mikolas also had success in his previous start against his rivals today. The Cardinals' starter earned his first win of the season against Cincinnati on April 30 with a 5.1-inning scoreless outing, with four strikeouts and only three hits allowed.
With a 9.5-run line and our Bet Labs recommendation for Sunday, the under is the appropriate pick for this game.
Reds vs Cardinals Prediction, Betting Analysis
This system targets Sunday MLB games where the home team is coming off one or two consecutive Overs, suggesting recent offensive outperformance or inflated totals.
The theory is that on Sundays — often the final game of a series and an early start — teams may rest key hitters, lineups can be inconsistent, and pitchers usually perform better against lineups they’ve already seen.
With an opening total in the 8-to-9.5-run range, the line is high enough to offer Under value when offensive regression is likely. Betting the under in these specific setups has historically yielded a positive return on investment (ROI) over time.
Sunday games usually wrap up the series and are played during the day, usually after a night game. Hitters may tend to be worn out by the end of the week, and collectively as a league, players tend to take their rest days on Sundays, so there's an added advantage towards Unders.
Pick: Under 9.5 (-118, BetMGM)
