The St. Louis Cardinals host the Cleveland Guardians on April 14, 2026. First pitch from Busch Stadium is scheduled for 7:45 p.m. EDT. The game will be broadcast on CLEG.
The Guardians are favored by -120 on the moneyline and by -1.5 on the run line. The Cardinals are +102 on the moneyline and +1.5 on the run line. The total is set at 8.5 runs.
Find my MLB picks and Guardians vs Cardinals prediction below, as well as probable pitchers, weather report, and more.
Guardians vs Cardinals Prediction
- Guardians vs Cardinals Pick: Over 8.5 (-110 or Better)
Guardians vs Cardinals Odds
| Guardians Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 +140 | 8.5 -110o / -110u | -120 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -170 | 8.5 -110o / -110u | +102 |
- Guardians vs Cardinals spread: Guardians -1.5 (+140), Cardinals +1.5 (-170)
- Guardians vs Cardinals over/under: 8.5 (-110o / -110u)
- Guardians vs Cardinals moneyline: Guardians -120, Cardinals +102
Guardians vs Cardinals Pitchers
| Joey Cantillo (LHP) | Stat | Michael McGreevy (RHP) |
|---|---|---|
| 1-0 | W-L | 1-1 |
| 0.6 | fWAR (FanGraphs) | 0.4 |
| 2.45 / 2.40 | ERA / xERA | 2.16 / 5.70 |
| 1.89 / 3.28 | FIP / xFIP | 3.13 / 4.14 |
| 1.23 | WHIP | 0.78 |
| 21.7% | K-BB% | 12.9% |
| 39.4% | GB% | 42.0% |
| 95 | Stuff+ | 76 |
| 92 | Location+ | 114 |
Guardians vs Cardinals MLB Betting Preview
Our own Sean Zerillo projects a decent edge on the Over in this matchup.
While the consensus line sits around 8.5, Zerillo projects 8.98 runs for this game, representing a nearly 4% edge against the market.
As a reminder, you can see all of Zerillo's MLB game projections with an Action PRO Subscription. Find his projected lines every day on the PRO Projections tab.
Guardians vs Cardinals Picks
There's plenty of great hitting weather around the league on Tuesday, including in St. Louis.
With winds blowing out toward left field at over 15 MPH and temperatures in the high-70s, BallParkPal projects a +4 run-scoring factor behind a +11% home run factor.
The Cardinals' offense has exceeded expectations in the early going, posting a 105 wRC+ against left-handed pitching behind Jordan Walker's monstrous improvements.
Meanwhile, Jose Ramirez and the Guardians will always manufacture runs, especially against Michael McGreevy's lackluster stuff (91.3 MPH fastball, 76 Stuff+, 5.70 xERA, 4.14 xFIP).
It's also worth noting that the Guardians' bullpen has been used frequently over the past few days, which could affect scoring in the later innings.
In today's edition of Opening Pitch, Zerillo wrote that the Over 8.5 at -110 or better is worth a play.
Pick: Over 8.5 (-110 or Better)
