The Washington Nationals (16-19) host the Cleveland Guardians (20-14) on May 6, 2025. First pitch from Nationals Park is scheduled for 3:35 p.m. ET; the game will be broadcast on MASN2.
Find our Guardians vs Nationals prediction and MLB player prop picks below.
Guardians vs Nationals Prediction, Game 1 Pick
- Guardians vs Nationals pick: Luis L. Ortiz Over 15.5 Pitching Outs
My Guardians vs Nationals best bet is on Luis L. Ortiz's pitching outs prop. Check our live MLB odds page to find the best odds.
Guardians vs Nationals Odds
May 6, 2025
3:35 p.m. EDT
MASN2
| Guardians Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
-1.5 +140 | 9.5 +100o / -120u | -120 |
| Nationals Odds | ||
|---|---|---|
| Spread | Over/Under | Moneyline |
+1.5 -170 | 9.5 +100o / -120u | +100 |
Odds via BetMGM. Get up-to-the-minute MLB odds here.
Guardians vs Nationals Projected Starting Pitchers
| RHP Luis L. Ortiz (CLE) | Stat | RHP Jake Irvin (WAS) |
|---|---|---|
| 2-3 | W-L | 2-1 |
| 0.4 | fWAR (FanGraphs) | 0.2 |
| 4.78 / 4.52 | ERA /xERA | 4.01 / 5.09 |
| 3.94 / 3.82 | FIP / xFIP | 4.80 / 4.02 |
| 1.41 | WHIP | 1.13 |
| 14.3% | K-BB% | 12.7% |
| 47.7% | GB% | 41.7% |
| 98 | Stuff+ | 95 |
| 94 | Location+ | 107 |
Nick Galaida’s Guardians vs Nationals Preview, Prediction
Cleveland Guardians Player Prop: Tremendous Value
Luis L. Ortiz is far from MLB’s most efficient pitcher.
Still, Guardians manager Steven Vogt will likely lean on him as much as possible in Game 1 of Tuesday’s doubleheader against the Guardians, especially at the beginning of a new week.
