The San Francisco Giants host the Colorado Rockies on September 26, 2025. First pitch from Oracle Park is scheduled for 10:15 p.m. EDT; the game will be broadcast on NBCS-BA.
Find my MLB betting preview and Rockies vs Giants prediction below, as well as probable pitchers, betting trends, injury reports and more.
My Rockies vs Giants Prediction
- Rockies vs Giants pick: Heliot Ramos Home Run (+650)
My Rockies vs Giants best bet is on Heliot Ramos to hit a home run tonight. Make sure to find the best odds by checking our live MLB odds page.
Rockies vs Giants Odds
| Rockies Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -105 | 8.5 -105o / -115u | +195 |
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -115 | 8.5 -105o / -115u | -245 |
Rockies vs Giants Projected Starting Pitchers
| RHP German Marquez (COL) | Stat | RHP Trevor McDonald (SF) |
|---|---|---|
| 3-15 | W-L | 0-0 |
| 0.6 | fWAR (FanGraphs) | 0.2 |
| 6.49 / 5.62 | ERA / xERA | 3.38 / 5.15 |
| 5.26 / 5.20 | FIP / xFIP | 2.89 / 3.66 |
| 1.70 | WHIP | 1.38 |
| 6.5 | K-BB% | 5.9 |
| 37.4 | GB% | 55.6 |
| 88 | Stuff+ | 91 |
| 95 | Location+ | 110 |
Rockies vs Giants Preview, Prediction, Betting Analysis
PRO Projections are out for Friday, September 26, featuring the full MLB slate. One of the top bets to watch is the late-night matchup between the Colorado Rockies and the San Francisco Giants.
Giants star Heliot Ramos is available at +650 odds to homer, which our proprietary model identifies as the best value play on the board. According to PRO’s analysis, Ramos carries a projected home run rate of 0.19, translating to a 4% edge compared to betting market odds.
The Rockies’ pitching staff has been particularly vulnerable to the long ball this year, surrendering 246 home runs, which is 28 more than any other team in MLB. Despite playing home games at Oracle Park, which is traditionally challenging for home runs, Ramos has demonstrated power, bashing 10 of his 20 in his home confines.
Statcast data further supports Ramos’ power potential, placing him in the 75th percentile or higher for bat speed, average exit velocity, and hard-hit percentage.
On the mound, Rockies starter German Marquez has struggled down the stretch, allowing a home run in 10 consecutive starts. The veteran right-hander has conceded six homers in his four September outings alone, making this an ideal scenario for the Giants to capitalize.
Our top value play is on Ramos to clear the fences.
Pick: Heliot Ramos Home Run (+650)
Rockies vs Giants Betting Trends
