The Chicago White Sox (37-66) and Chicago Cubs (60-42) will face off in the MLB tonight. First pitch from Rate Field is scheduled for 7:40 p.m. ET. The game will broadcast live on CHSN.
The Cubs are -185 favorites to win outright on the moneyline, while the White Sox are +150 to pull off the upset. The over/under is set at 8 total runs.
Continue below for my Cubs vs White Sox predictions and MLB picks for Friday, July 25, as well as probable pitchers, betting trends, injury reports and more.
My Cubs vs White Sox Prediction
- Cubs vs White Sox pick: First Five Innings Under 4.5 Runs (-120)
My White Sox vs. Cubs best bet is on the first five innings under, with the best line currently available at DraftKings. But as always, make sure to find the best odds by checking our live MLB odds page.
Cubs vs White Sox Odds
| Cubs Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-1.5 -105 | 8 -110o / -110u | -185 |
| White Sox Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+1.5 -115 | 8 -110o / -110u | +150 |
Cubs vs White Sox Preview, Picks
This MLB first five innings system titled "Low Total Unders with Line Movement (F5)" is built around early-game environments where oddsmakers and sharp bettors anticipate limited scoring, which appears to be the situation in tonight's matchup between the Cubs and White Sox.
The foundation starts with a low closing total — between 3.5 and 6.5 — indicating a strong pitcher’s duel or poor hitting conditions.
If the full game total has moved down between half a run and one run from open to close, it signals smart money pushing the market toward the under.
The model further refines this edge by requiring the juice on the under to remain within a sharp range, typically between -149 and -120, avoiding inflated pricing that could distort value.
Games played in modest wind conditions — between four and nine miles per hour — are included, as they often suppress offense without triggering dramatic public reaction.
By isolating games across the past three seasons and targeting first-half unders in tightly lined, downward-trending markets, this system captures value where the market signals defensive control without overreaction
Cubs vs White Sox Best Bet
- First Five Innings Under 4.5 (-120)
